Supersusceptibility to hydrophobic antimicrobial agents and cell surface hydrophobicity in Branhamella catarrhalis

FEMS Microbiology Letters
N GotohT Nishino

Abstract

To clarify the cause of the supersusceptibility of Branhamella catarrhalis to macrolide antibiotics, which are well-known to be inactive to most Gram-negative bacteria, we determined its cell surface hydrophobicity by the partition experiment between water and hydrocarbons. Its cell surface was found to be markedly more hydrophobic than that of Escherichia coli or Pseudomonas aeruginosa cells. This suggested that the outer membrane of B. catarrhalis plays no role as a diffusion barrier towards hydrophobic agents.

References

Nov 1, 1987·The Journal of Antimicrobial Chemotherapy·G L Ridgway
Nov 1, 1987·The Journal of Antimicrobial Chemotherapy·L Dubreuil
Nov 1, 1987·The Journal of Antimicrobial Chemotherapy·J C Pechére, R Auckenthaler
Jan 1, 1984·Annual Review of Microbiology·R E Hancock

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Citations

May 1, 1992·Diagnostic Microbiology and Infectious Disease·R C Spencer, P F Wheat
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·H WakebeY Yabuuchi
Apr 28, 1989·Biochemical and Biophysical Research Communications·H FuruyaY Fujii-Kuriyama

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