Supervoxels-Based Histon as a New Alzheimer's Disease Imaging Biomarker

Sensors
César A Ortiz ToroErnestina Menasalvas Ruiz

Abstract

Alzheimer's disease (AD) represents the prevalent type of dementia in the elderly, and is characterized by the presence of neurofibrillary tangles and amyloid plaques that eventually leads to the loss of neurons, resulting in atrophy in specific brain areas. Although the process of degeneration can be visualized through various modalities of medical imaging and has proved to be a valuable biomarker, the accurate diagnosis of Alzheimer's disease remains a challenge, especially in its early stages. In this paper, we propose a novel classification method for Alzheimer's disease/cognitive normal discrimination in structural magnetic resonance images (MRI), based on the extension of the concept of histons to volumetric images. The proposed method exploits the relationship between grey matter, white matter and cerebrospinal fluid degeneration by means of a segmentation using supervoxels. The calculated histons are then processed for a reduction in dimensionality using principal components analysis (PCA) and the resulting vector is used to train an support vector machine (SVM) classifier. Experimental results using the OASIS-1 database have proven to be a significant improvement compared to a baseline classification made using the pip...Continue Reading

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Citations

Nov 26, 2019·Computers in Biology and Medicine·Ricardo Mendoza-LéonMarcela Hernández Hoyos

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Methods Mentioned

BETA
PCA
feature extraction

Software Mentioned

learn
OASIS
Open Access Series of Imaging Studies ( OASIS )
scikit
Clinica
MATLAB
SPM ( Statistical Parametric Mapping )
DARTEL
SPM
SLIC

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