Superwettable Electrochemical Biosensor toward Detection of Cancer Biomarkers

ACS Sensors
Tailin XuShutao Wang

Abstract

Bioinspired superwettable micropatterns that combine two extreme states of superhydrophobicity and superhydrophilicity with the ability to enrich and absorb microdroplets are suitable for versatile and robust sensing applications. Here we introduce a superwettable microchip that integrates superhydrophobic-superhydrophilic micropatterns and a nanodendritic electrochemical biosensor toward the detection of prostate cancer biomarkers. On the superwettable microchip, the superhydrophobic area could confine the microdroplets in superhydrophilic microwells; such behavior is extremely helpful for reducing the amount of analytical solution. In contrast, superhydrophilic microwells exhibit a high adhesive force toward microdroplets, and the nanodendritic structures can improve probe-binding capacity and response signals, thus greatly enhancing the sensitivity. Sensitive and selective detection of prostate cancer biomarkers including miRNA-375, miRNA-141, and prostate-specific antigen on a single microchip is also achieved. Such a superwettable microchip with high sensitivity, low sample volume, and upside-down detection capability in a single microdroplet shows great potential to fabricate portable devices toward complex biosensing app...Continue Reading

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Citations

Jan 22, 2019·Chemical Communications : Chem Comm·Yongchao SongXueji Zhang
May 17, 2019·Chemical Society Reviews·Tailin XuShutao Wang
Jun 20, 2019·Biomaterials Science·Karim Khanmohammadi ChenabAtyeh Rahmanzadeh
Jan 30, 2020·Biomaterials Science·Haifeng Fan, Zhiguang Guo
Aug 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuemeng YangShutao Wang
Dec 31, 2020·Biomedicines·Intan Rosalina SuhitoTae-Hyung Kim
Aug 10, 2021·Advanced Science·Lingyu SunYuanjin Zhao
Mar 19, 2019·Analytical Chemistry·Xuecheng HeXueji Zhang
Nov 10, 2018·Analytical Chemistry·Xuecheng HeXueji Zhang

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