Superwettable Microwell Arrays Constructed by Photocatalysis of Silver-Doped-ZnO Nanorods for Ultrasensitive and High-Throughput Electroanalysis of Glutathione in Hela Cells

ACS Applied Materials & Interfaces
Min LiuHua Wang

Abstract

Superwettable microwell arrays were constructed for the first time by the synergic photocatalysis of silver-doped-ZnO (Ag-ZnO) nanorods patterned on indium tin oxide (ITO) electrodes for electroanalysis of glutathione (GSH) in hela cells through the signal output of AgCl electrochemistry. The newly prepared Ag-ZnO nanorods with high photocatalysis were dispersed into an octadecyltrichlorosilane (OTS) matrix to be deposited onto ITO substrates, yielding superhydrophobic Ag-ZnO-OTS coatings. Superhydrophilic microwells were further created by the Ag-ZnO photocatalysis under UV irradiation to produce Ag-ZnO microwell arrays featuring the superwettability profile. The resulting Ag-ZnO microwell-modified ITO electrodes were employed further for electroanalysis of GSH through solid-state AgCl electrochemistry, in which the specific Ag-GSH interactions would trigger a rational decrease in the sharp AgCl peak currents at the potential approaching zero. Moreover, benefitting from the superwettability feature, the microwells on the ITO electrodes could facilitate the condensing enrichment of GSH analytes from the sample droplets, achieving improved analysis sensitivity. The as-developed electroanalysis strategy was subsequently demonstra...Continue Reading

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Citations

Jan 30, 2020·Biomaterials Science·Haifeng Fan, Zhiguang Guo
Apr 13, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fuming SangZhizhou Zhang
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qianru MaYufen Zhao

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