PMID: 7543634Aug 1, 1995Paper

Supplemental L-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury

The Journal of Thoracic and Cardiovascular Surgery
H SatoJ Vinten-Johansen

Abstract

Unenhanced hypothermic cardioplegia does not prevent postischemic endothelial and contractile dysfunction in hearts subjected to antecedent regional or global ischemia. This study tested the hypothesis that supplementing blood cardioplegic solution and reperfusion with the nitric oxide precursor L-arginine would preserve endothelial function, reduce infarct size, and reverse postcardioplegia regional contractile dysfunction by the L-arginine-nitric oxide pathway. In 23 anesthetized dogs, the left anterior descending coronary artery was ligated for 90 minutes, after which total bypass was established for surgical "revascularization." In 10 dogs, unsupplemented multidose hypothermic blood cardioplegic solution was administered for a total of 60 minutes of cardioplegic arrest. In eight dogs, L-arginine was given intravenously (4 mg/kg per minute) and in blood cardioplegic solution (10 mmol) during arrest. In five dogs, the nitric oxide synthesis blocker N omega-nitro-L-arginine (1 mmol) was used to block the L-arginine-nitric oxide pathway during cardioplegia and reperfusion. Infarct size (triphenyltetrazolium chloride) as percent of the area at risk was significantly reduced by L-arginine compared with blood cardioplegic solution...Continue Reading

Associated Clinical Trials

References

Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Oct 31, 1991·Biochemical and Biophysical Research Communications·R G BogleG E Mann
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jun 1, 1990·The Annals of Thoracic Surgery·H YokoyamaA R Cordell
Oct 31, 1989·Biochemical and Biophysical Research Communications·M E GoldL J Ignarro
Sep 1, 1989·Cardiovascular Research·J Vinten-JohansenA R Cordell
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Apr 1, 1987·British Journal of Pharmacology·B FurlongJ A Smith
Sep 1, 1986·The Annals of Thoracic Surgery·J Vinten-JohansenA R Cordell
Dec 1, 1982·Circulation·E Braunwald, R A Kloner
Sep 1, 1994·The Annals of Thoracic Surgery·D A HudspethD G Van Wylen
Jul 1, 1994·The Annals of Thoracic Surgery·K NakanishiJ W Hammon

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Citations

Jan 1, 1997·Surgery Today·Y Nonami
Sep 1, 1995·The Annals of Thoracic Surgery·J Vinten-JohansenH Sato
Jul 1, 1995·International Journal of Cardiology·J Vinten-JohansenZ Q Zhao
Dec 15, 2005·Heart, Lung & Circulation·Guo-Wei He
Jan 16, 2002·The Annals of Thoracic Surgery·Y YanJ P Kantelip
Sep 2, 1998·The Annals of Thoracic Surgery·H L LazarJ F Keaney
Oct 13, 1998·The Annals of Thoracic Surgery·B L BufkinR A Guyton
Jul 1, 1998·Clinical Biochemistry·G EllisS K Makela
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Gábor SzabóAlexander Juhász-Nagy
Dec 31, 1997·The Journal of Thoracic and Cardiovascular Surgery·G ChampsaurM Franck
Feb 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·M S BhabraT L Hooper
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M DesroisM Bernard
Nov 5, 1999·Clinical and Experimental Pharmacology & Physiology·G W He
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·G W He
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·P FerdinandyA Tosaki
Jul 1, 1995·Journal of Cardiac Surgery·J W Hammon, J Vinten-Johansen
Mar 24, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·B L LopezX L Ma
Sep 18, 2001·Heart·R D Rakhit, M S Marber
Jun 28, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Emmanuel Eroume A EgomMing Lei
Jun 24, 2006·World Journal of Surgery·Dan L WaitzbergDavid Bihari
Jan 5, 2001·Expert Opinion on Investigational Drugs·A LermanJ L Velianou
Aug 5, 2000·The Journal of Thoracic and Cardiovascular Surgery·R D RileyJ Vinten-Johansen
Feb 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·A MizunoL J Ignarro
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·M T KrononM Ilbawi
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·M T KrononM Ilbawi
May 12, 1998·The Journal of Thoracic and Cardiovascular Surgery·T MizunoM Sunamori
Oct 24, 1997·The Journal of Thoracic and Cardiovascular Surgery·G W He, C Q Yang
Jun 1, 1996·The Annals of Thoracic Surgery·M CarrierL C Pelletier
Jul 1, 1998·The Annals of Thoracic Surgery·I G DuarteR A Guyton
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Manuel CastelláLouis J Ignarro

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