Supplementation of a standardized extract from Phyllanthus emblica improves cardiovascular risk factors and platelet aggregation in overweight/class-1 obese adults

Journal of Medicinal Food
Savita KhannaSashwati Roy

Abstract

The objective of this study (clinicaltrials.gov NCT01858376) was to determine the effect of oral supplementation of a standardized extract of Phyllanthus emblica (CAPROS(®)) on cardiovascular disease (CVD) risk factors in overweight adult human subjects from the US population. Overweight/Class-1 obese (body-mass index: 25-35) adult subjects received 500 mg of CAPROS supplement b.i.d for 12 weeks. The study design included two baseline visits followed by 12 weeks of supplementation and then 2 weeks of washout. At all visits, peripheral venous blood was collected in sodium citrate tubes. Lipid profile measurements demonstrated a significant decrease in calculated low-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein following 12 weeks of CAPROS supplementation when compared to averaged baseline visits. Circulatory high-sensitivity C reactive protein (hs-CRP) levels were significantly decreased after 12 weeks of supplementation. In addition, both ADP- and collagen-induced platelet aggregation was significantly downregulated following 12 weeks of supplementation. Overall, the study suggests that oral CAPROS supplementation may provide beneficial effects in overweight/Class-1 obese adults by lowering mul...Continue Reading

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Citations

May 20, 2016·Rapid Communications in Mass Spectrometry : RCM·Madhu Poornima MamidalaVidya Rajesh
Jun 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bhavesh C VariyaSnehal S Patel
Jul 16, 2016·Journal of Medicinal Food·Amitava DasSashwati Roy
Nov 6, 2018·Journal of Cardiovascular and Thoracic Research·Fataneh Hashem-DabaghianSaeed Kianbakht
Feb 23, 2020·Journal of Alzheimer's Disease : JAD·Elham TeimouriRalph N Martins
Nov 30, 2021·Nutrition and Cancer·Gaurav KumarChinthalapally V Rao

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT01858376

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