Supplementation of broccoli or Bifidobacterium longum-fermented broccoli suppresses serum lipid peroxidation and osteoclast differentiation on alveolar bone surface in rats fed a high-cholesterol diet

Nutrition Research
Takaaki TomofujiManabu Morita

Abstract

High-cholesterol diet enhances osteoclastic activity on alveolar bone by increasing serum lipid peroxidation. We hypothesized that supplementation with dietary antioxidants, such as found in broccoli and its fermented products, might suppress increases in serum lipid peroxidation, contributing to the inhibition of osteoclastic activity after high-cholesterol diet intake. The purpose of the present study was to investigate the effects of broccoli and fermented broccoli consumption on serum lipid peroxidation and osteoclast differentiation in alveolar bone of rats fed a high-cholesterol diet. In this 12-week study, rats were divided into 4 groups (n = 6/group): a control group (fed regular diet) and 3 experimental groups (fed a high-cholesterol [1% wt/wt] diet, or a high-cholesterol diet supplemented with either broccoli powder [5% wt/wt] or Bifidobacterium longum-fermented broccoli powder [5% wt/wt]). Serum hexanoyl-lysine (HEL) levels were measured as a parameter of lipid peroxidation. The number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts in alveolar bone was enumerated to evaluate osteoclast differentiation. When compared with regular diet, the high-cholesterol diet increased serum HEL levels and result...Continue Reading

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Citations

Mar 4, 2014·TheScientificWorldJournal·Kolsoom ParvanehReza Erfani
Oct 1, 2015·Current Osteoporosis Reports·Laura McCabeNarayanan Parameswaran
Mar 19, 2014·Chemistry and Physics of Lipids·Alexej V SokolovOleg M Panasenko
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Aug 30, 2017·Cold Spring Harbor Perspectives in Medicine·Roberto Pacifici
Feb 10, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y Luo, W C Blackledge
Apr 10, 2019·Nutrients·Despoina E KiousiAlex Galanis
May 30, 2021·BMC Complementary Medicine and Therapies·Nima Montazeri-NajafabadyAhmad Gholami
Aug 26, 2017·Microbiology Spectrum·Fraser L CollinsLaura R McCabe

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