Supplementation with essential amino acids in middle age maintains the health of rat kidney

International Journal of Immunopathology and Pharmacology
G CorsettiR Rezzani

Abstract

Chronic kidney diseases are a social and economic problem, and diet has long been recognized as a fundamental modulator of kidney health in human and experimental models. Age-dependent alterations in mitochondrial function play a crucial role in the development of diseases of aging, and mitochondrial disorders have been observed in experimental models of kidney failure. Recently, the beneficial dietary effect of a specific mixture of essential amino acids (EAA) has been studied in elderly subjects, but no data were collected from the kidney. The aim of this study was to assess whether daily supplementation of the diet with EAA at the beginning of senescence could preserve renal health. We used middle-aged (18-month-old) male Wistar rats fed a standard diet and water ad libitum (M-aged group) or a diet with added EAA (1.5 g/kg per day) dissolved in drinking water for 3 months (M-aged+EAA group). Young (2-month-old) rats fed a standard diet for 3 months were used as controls. Mitochondrial morphology and markers for collagen, cyt-c-oxidase, HSP60, GRP75, eNOS, iNOS, Bax, Bcl2 and VEGF were analyzed in glomeruli and tubules. EAA supplementation limited fibrosis and increased the capillary tuft area in the glomeruli of M-aged rats....Continue Reading

References

Mar 1, 1986·The American Journal of Medicine·S Anderson, B M Brenner
Oct 27, 1994·Nature·H C SchneiderW Neupert
Sep 18, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B C Kone
Sep 3, 1998·Histopathology·S J NaylerK Cooper
Aug 6, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H PetersN A Noble
May 25, 2001·Journal of the American Society of Nephrology : JASN·Jacques BernhardDenis Fouque
Oct 30, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Pollack, C Leeuwenburgh
Aug 29, 2002·The EMBO Journal·Quan ZhaoNicholas J Hoogenraad
Sep 6, 2002·Experimental Gerontology·Hyon Jeen KimHae Young Chung
Jan 7, 2003·Toxicologic Pathology·Ghanta N Rao
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David Julian, Christiaan Leeuwenburgh
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Stephen AdlerPawel M Kaminski
Oct 19, 2004·Experimental Gerontology·Ji Hyeon LeeHae Young Chung
Nov 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Enzo NisoliEmilio Clementi
Mar 22, 2005·European Journal of Applied Physiology·Maria Antonietta PellegrinoGiuseppe D'Antona
Jul 27, 2005·Nephron. Experimental Nephrology·David A LongRichard J Johnson
Nov 18, 2005·Methods in Enzymology·Yashige KotakeRobert A Floyd
Nov 29, 2005·Experimental Gerontology·E HütterE Gnaiger
Mar 3, 2006·Nephrology·Sreedhar Mandayam, William E Mitch
May 9, 2006·Experimental Gerontology·Anne-Laure BulteauBertrand Friguet
Jul 5, 2006·Cell Stress & Chaperones·Custer C DeocarisRenu Wadhwa
Jul 28, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David J BakerRussell T Hepple
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Susan H McKiernanJudd M Aiken
Jun 26, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Claire E LeeRichard D Griffiths
Jul 31, 2007·Ageing Research Reviews·M Shawkat Razzaque
Oct 28, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vandana MenonMark J Sarnak
May 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Gregory C HendersonK Sreekumaran Nair
Jun 9, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Mary B SundellT Alp Ikizler

❮ Previous
Next ❯

Citations

Jul 19, 2011·Journal of Cachexia, Sarcopenia and Muscle·Francesco S Dioguardi
Oct 8, 2011·International Journal of Immunopathology and Pharmacology·Giovanni CorsettiR Rezzani
Jun 1, 2011·Journal of Nutrigenetics and Nutrigenomics·Francesco Saverio Dioguardi
Apr 5, 2013·Journal of the International Society of Sports Nutrition·Lorenza BroccaGiuseppe D'Antona

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.