Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Janie AllaireBenoît Lamarche

Abstract

Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (O3I), which is calculated as the proportion of EPA and DHA in red blood cell (RBC) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the O3I in men and women with abdominal obesity and subclinical inflammation. In a double-blind controlled crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three treatment phases: 1-2.7g/d of EPA, 2-2.7g/d of DHA, and 3-3g/d of corn oil (0g of EPA+DHA). All supplements were provided as 3×1g capsules for a total of 3g/d. The 10-week treatment phases were separated by nine-week washouts. RBC membrane fatty acid composition and O3I were assessed at baseline and the end of each phase. Differences in O3I between treatments were assessed using mixed models for repeated measures. The increase in the O3I after supplementation with DHA (+5.6% compared with control, P<0.0001) was significantly greater than after EPA (+3.3% compared with c...Continue Reading

Citations

Jan 31, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hao WangLiang Zhao
May 31, 2018·The Journal of Clinical Endocrinology and Metabolism·Janie AllaireBenoît Lamarche
Mar 2, 2018·Critical Reviews in Food Science and Nutrition·Samaneh Ghasemi FardGiovanni M Turchini
Aug 10, 2019·The American Journal of Clinical Nutrition·Rachel E WalkerWilliam S Harris
Oct 31, 2017·Nutrients·Narcis TribulovaJan Slezak
Mar 28, 2018·The British Journal of Nutrition·Aline Haas de MelloGislaine Tezza Rezin
Feb 10, 2018·International Journal of Molecular Sciences·Jacqueline K Innes, Philip C Calder
May 8, 2018·Molecular Neurobiology·Aline Haas de MelloGislaine Tezza Rezin
Jan 31, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Arash AsherWilliam S Harris
May 9, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L LjungbladP Kogner

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