Supplementation with n-3, n-6, n-9 fatty acids in an insulin-resistance animal model: does it improve VLDL quality?

Food & Function
D LuceroV Zago

Abstract

Insulin-resistance (IR), of increased cardiovascular risk, is characterized by the production of altered VLDL with greater atherogenicity. Dietary fatty acids influence the type of circulating VLDL. But, it is not clear how dietary fatty acids impact VLDL characteristics in IR. to evaluate the effects of n-3, n-6 and n-9 fatty acid supplementation on preventing atherogenic alterations in VLDL, in a diet-induced IR rat model. Male Wistar rats (180-200 g) were fed: standard diet (control, n = 8) and a sucrose rich diet (30% sucrose in water/12 weeks, SRD; n = 24). Simultaneously, SRD was subdivided into SRD-C (standard diet), and three other groups supplemented (15% w/w) with: fish oil (SRD-n3), sunflower oil (SRD-n6) and high oleic sunflower oil (SRD-n9). Lipid profile, free fatty acids, glucose, and insulin were measured. Isolated VLDL (d < 1.006 g ml(-1)) was characterized by chemical composition and size (size exclusion-HPLC). In comparison with SRD-C: SRD-n3 showed an improved lipoprotein profile (p < 0.01), with lower levels of insulin and HOMA-IR (p < 0.05). SRD-n6 showed increased levels of HDL-cholesterol and lower insulin levels. SRD-n9 did not exhibit differences in lipid and IR profile, and even favored weight gain an...Continue Reading

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Citations

Oct 27, 2017·Nutrients·Priscila Silva FigueiredoPriscila Aiko Hiane
Jan 13, 2018·International Journal of Molecular Sciences·Alex Buoite StellaMichela Zanetti
Jun 21, 2019·Food & Function·Bárbara Pereira da SilvaHércia Stampini Duarte Martino
Feb 6, 2019·Food Research International·Bárbara Pereira da SilvaHércia Stampini Duarte Martino
Mar 21, 2021·European Journal of Clinical Nutrition·Izabela da Silva SantosDaniela Saes Sartorelli

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