Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Christian MeierM J Seibel

Abstract

Bone metabolism follows a seasonal pattern with high bone turnover and bone loss during the winter. In a randomized, open-label 2-year sequential follow-up study of 55 healthy adults, we found that supplementation with oral vitamin D3 and calcium during winter abolished seasonal changes in calciotropic hormones and markers of bone turnover and led to an increase in BMD. Supplementation with oral vitamin D3 and calcium during the winter months seems to counteract the effects of seasonal changes in vitamin D and thus may be beneficial as a primary prevention strategy for age-related bone loss. Bone metabolism follows a seasonal pattern characterized by high bone turnover and bone loss during winter. We investigated whether wintertime supplementation with oral vitamin D3 and calcium had beneficial effects on the circannual changes in bone turnover and bone mass. This prospective study comprised an initial observation period of 12 months ("year 1"), followed by an intervention during parts of year 2. Fifty-five healthy subjects living in southwestern Germany (latitude, 49.5 degrees N) were randomized into two groups: 30 subjects were assigned to the treatment group and received oral cholecalciferol (500 IU/day) and calcium (500 mg/...Continue Reading

References

Jan 27, 1979·British Medical Journal·E M PoskittD E Lawson
May 1, 1979·The Journal of Clinical Endocrinology and Metabolism·R P StrydM N Brunden
Aug 4, 1979·British Medical Journal·D E LawsonM Davie
Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Nov 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C CooperL J Melton
Aug 1, 1991·Calcified Tissue International·D VanderschuerenR Bouillon
Jan 1, 1991·Chronobiology International·A MattesB Lemmer
May 2, 1990·JAMA : the Journal of the American Medical Association·E L Schneider, J M Guralnik
Sep 27, 1990·The New England Journal of Medicine·B Dawson-HughesS Tannenbaum
Apr 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E J BergstralhL J Melton
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S S ShermanJ D Tobin
Dec 28, 1989·The New England Journal of Medicine·E A KrallB Dawson-Hughes
Nov 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·K ThomsenL Mosekilde
Apr 1, 1987·The American Journal of Clinical Nutrition·R A BouillonW K Pelemans
Feb 22, 1974·Nature·T C Stamp, J M Round
Aug 1, 1980·European Journal of Clinical Investigation·C ChristiansenI Transbøl
Apr 23, 1994·BMJ : British Medical Journal·M C ChapuyP J Meunier
Oct 29, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·S WildermuthJ L O'Riordan
Feb 18, 1993·The New England Journal of Medicine·I R ReidS J Sharpe
Apr 1, 1996·Journal of Clinical Pathology·A S DouglasS P Robins
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R R ReckerD B Kimmel
Sep 4, 1997·The New England Journal of Medicine·B Dawson-HughesG E Dallal
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·H W WoitgeM J Seibel
Mar 12, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsL J Melton
Jun 13, 1998·The American Journal of Clinical Nutrition·S S Harris, B Dawson-Hughes
Jul 31, 1998·European Journal of Clinical Nutrition·A ZittermannP Stehle
Aug 25, 1999·Metabolism: Clinical and Experimental·H M PerryP J Garry
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H W WoitgeM J Seibel
Jun 26, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R PatelI Fogelman
Nov 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C J Lamberg-AllardtL M Valsta
Feb 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V CarnevaleA Scillitani
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Prema B RapuriVera Haynatzka
May 30, 2002·The American Journal of Medicine·Vin TangprichaMichael F Holick
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aubrey BlumsohnRichard Eastell
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Markus J SeibelBjoern Lemmer
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erik Roj LarsenAnders Foldspang

❮ Previous
Next ❯

Citations

Jul 28, 2011·Nutrition Reviews·Sangita SharmaAndre Corriveau
May 13, 2014·BoneKEy Reports·Peter R Ebeling
Aug 31, 2011·Journal of Osteoporosis·Evelien GielenSabine Verschueren
Dec 18, 2008·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Carol L WagnerBruce W Hollis
Jul 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David A HanleyUNKNOWN Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada
Jul 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David A HanleyUNKNOWN Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada
Feb 4, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Sherri-Ann M Burnett-BowieJoel S Finkelstein
May 19, 2012·The Journal of Clinical Endocrinology and Metabolism·Lars RejnmarkBo Abrahamsen
Apr 21, 2009·International Journal of Epidemiology·O M DekkersJ P Vandenbroucke
Oct 4, 2005·The British Journal of Nutrition·Armin ZittermannReiner Koerfer
Apr 8, 2010·The British Journal of Nutrition·George MoschonisYannis Manios
Jul 31, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Carol L WagnerBruce W Hollis
Dec 16, 2005·Photochemistry and Photobiology·Antony R Young, Susan L Walker
Dec 14, 2005·Clinical Endocrinology·Christian MeierMarkus J Seibel
May 18, 2006·The British Journal of Dermatology·B Diffey
May 7, 2016·Nature Reviews. Endocrinology·Susanne RautiainenHoward D Sesso
May 30, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·John A ShepherdUNKNOWN International Society for Clinical Densitometry Committee on Standards of Bone Measurement
Apr 22, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Markus HerrmannMarkus Seibel
Sep 15, 2016·Scientific Reports·Li LiJoel T Dudley
Nov 23, 2006·Arquivos brasileiros de endocrinologia e metabologia·Markus J Seibel
Mar 13, 2009·Journal of the American Dietetic Association·Nancy R RodriguezUNKNOWN American College of Sports Medicine: Nutrition and Athletic Performance
Apr 10, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anders OdénHelena Johansson
Nov 1, 2010·Nutrients·Karen Plawecki, Karen Chapman-Novakofski
Jul 1, 2010·Nutrients·Eamon LairdJulie Wallace
Jul 12, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshihiro SatoKei Satoh
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robin M DalyCaryl Nowson
Jul 13, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J E P RockellT J Green
Sep 19, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G GuardiaD Sudhaker Rao
Apr 16, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kun ZhuRichard L Prince
Apr 28, 2005·Alimentary Pharmacology & Therapeutics·D McCarthyK D Cashman
Jun 13, 2008·The Journal of Nutrition, Health & Aging·E P CherniackS Levis
Feb 20, 2009·Medicine and Science in Sports and Exercise·Nancy R RodriguezSusie Langley

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Next ❯

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