Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy

Respiratory Medicine
Fernando De BenedettoInterdisciplinary Association for Research in Lung Disease (AIMAR) Study Group

Abstract

Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer®) - a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function - and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O2 therapy. One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured. Ninety patient...Continue Reading

Citations

Nov 30, 2019·Metabolites·Dimitris TsoukalasAristides Tsatsakis
Mar 27, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Juntuo ZhouYuxin Yin
Jan 3, 2021·Free Radical Biology & Medicine·Linhui LiChing-Hsien Chen
Jan 15, 2021·COPD·V I ZozinaA Corlateanu
Oct 30, 2020·International Journal of Molecular Sciences·Francisco Miguel Gutierrez-MariscalJose López-Miranda
Jun 12, 2021·Pneumologie·Konrad Schultz, Andreas Rembert Koczulla

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