Supplementation with Seabuckthorn Oil Augmented in 16:1n-7t Increases Serum Trans-Palmitoleic Acid in Metabolically Healthy Adults: A Randomized Crossover Dose-Escalation Study.

The Journal of Nutrition
Neil K HuangDariush Mozaffarian

Abstract

In animal models cis-palmitoleic acid (9-hexadecenoic acid; 16:1n-7c), a lipokine, improves insulin sensitivity, inflammation, and lipoprotein profiles; in humans trans-palmitoleic acid (16:1n-7t) has been associated with lower incidence of type 2 diabetes. The response to dose-escalation of supplements containing cis- and trans-palmitoleic acid has not been evaluated. We examined dose-escalation effects of oral supplementation with seabuckthorn oil and seabuckthorn oil augmented in 16:1n-7t on serum phospholipid fatty acids (PLFAs). Thirteen participants (7 women and 6 men; age 48 ± 16 y, BMI 30.4 ± 3.7 kg/m2) participated in a randomized, double-blind, crossover, dose-escalation trial of unmodified seabuckthorn oils relatively high in 16:1n-7c (380, 760, and 1520 mg 16:1n-7c/d) and seabuckthorn oils augmented in 16:1n-7t (120, 240, and 480 mg 16:1n-7t/d). Each of the 3 escalation doses was provided for 3 wk, with a 4-wk washout period between the 2 supplements. At the end of each dose period, fasting blood samples were used to determine the primary outcomes (serum concentrations of the PLFAs 16:1n-7t and 16:1n-7c) and the secondary outcomes (glucose homeostasis, serum lipids, and clinical measures). Trends across doses were e...Continue Reading

Associated Clinical Trials

References

Aug 13, 1998·The American Journal of Clinical Nutrition·A WolkP Barrefors
Jun 30, 2004·International Journal of Food Sciences and Nutrition·L S MaguireN M O'Brien
Oct 8, 2008·Journal of Lipid Research·Young-Ah MoonJay D Horton
Mar 12, 2010·The American Journal of Clinical Nutrition·Renata MichaDariush Mozaffarian
Oct 15, 2010·The American Journal of Clinical Nutrition·Dariush MozaffarianGökhan S Hotamisligil
Dec 22, 2010·Annals of Internal Medicine·Dariush MozaffarianGökhan S Hotamisligil
Feb 15, 2013·The American Journal of Clinical Nutrition·Dariush MozaffarianJennifer A Nettleton
Mar 19, 2014·Metabolism: Clinical and Experimental·Kristin M HirahatakeSean H Adams
Nov 28, 2014·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Susan K DuckettNathan M Long
Mar 13, 2016·Lipids·Alan A HennessyCatherine Stanton
Oct 12, 2018·PLoS Medicine·Fumiaki ImamuraUNKNOWN Fatty Acids and Outcomes Research Consortium (FORCE)
May 18, 2019·Nature Reviews. Cardiology·Jason H Y WuDariush Mozaffarian
Jun 16, 2019·The Journal of Nutritional Biochemistry·Maura E WalkerAlice H Lichtenstein

❮ Previous
Next ❯

Citations

May 8, 2021·The British Journal of Nutrition·Lidia Irasema Chávaro-OrtizMaría E Frigolet
Jul 21, 2021·Chinese Medicine·Xiuzhu LiShengpeng Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Vivek VashishthaBhuvnesh Kumar
Lipids in Health and Disease
Aleksandra Zielińska, Izabela Nowak
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Shi-Zhe Wang, U Shou-Han
© 2021 Meta ULC. All rights reserved