Abstract
Previous meta-analyses of interventional trials with vitamin E provided negative results but it remains unclear if this vitamin has some influence on cardiovascular events when supplemented alone. The aim of this study was to compare the effect of vitamin E alone or in combination with other antioxidants on myocardial infarction. Pubmed, ISI Web of Science, SCOPUS and Cochrane database were searched without language restrictions. We investigated randomized clinical trials studying the effect of vitamin E supplementation on myocardial infarction. Sixteen randomized controlled trials of vitamin E treatment were analyzed in this meta-analysis. The dose range for vitamin E was 33-800IU. Follow-up ranged from 0.5 to 9.4 years. Compared to controls, vitamin E given alone significantly decreased myocardial infarction (3.0% vs 3.4%) (random effects R.R.: 0.82; 95% C.I., 0.70-0.96; p = 0.01). This effect was driven by reduction of fatal myocardial infarction (random effects R.R.: 0.84; 95% C.I., 0.73-0.96; p = 0.01). When supplemented alone, vitamin E reduces myocardial infarction in interventional trials while it appears ineffective when associated with other antioxidants.
Citations
Dec 17, 2015·International Journal of Molecular Sciences·Assunta RaiolaMaria Manuela Rigano
Aug 21, 2015·The British Journal of Nutrition·Daniel RaederstorffManfred Eggersdorfer
Oct 25, 2016·International Journal of Molecular Sciences·Fereidoon Shahidi, Adriano Costa de Camargo
Nov 12, 2016·International Journal of Molecular Sciences·Rocio de la IglesiaAna Ramirez de Molina
Nov 7, 2016·Free Radical Biology & Medicine·Francesco GalliNesrin Kartal Özer
Aug 18, 2017·Antioxidants & Redox Signaling·Francesco VioliDaniele Pastori
Jun 9, 2018·Molecular Nutrition & Food Research·Lingyu ZhangYuming Wang
Aug 14, 2019·The Korean Journal of Thoracic and Cardiovascular Surgery·Chul KimSoon Kim
Jul 18, 2019·Annals of Rehabilitation Medicine·Chul KimSoon Kim
Sep 25, 2017·Nutrition Reviews·Arrigo F G CiceroMaciej Banach
Aug 24, 2019·Nutrients·Flori LorenzoTestai Lara
Feb 2, 2019·Mini Reviews in Medicinal Chemistry·Khairul Anwar ZarkasiZakiah Jubri
Aug 20, 2019·Platelets·Gennadi Kobzar
Oct 28, 2019·Korean Circulation Journal·Chul KimSoon Kim
Dec 7, 2018·Nutrients·Sebastià GalmésAndreu Palou
Feb 20, 2019·IUBMB Life·Erdi SozenNesrin Kartal Ozer
Aug 26, 2018·Nutrients·Arrigo F G CiceroStefano Bellentani
Oct 9, 2019·Journal of Clinical Biochemistry and Nutrition·Chuanlong FanJing Xiao
Jan 8, 2020·International Journal of Molecular Sciences·Arno R BourgonjeJumana Saleh
May 22, 2018·Current Atherosclerosis Reports·Paola Toledo-Ibelles, Jaime Mas-Oliva
Sep 11, 2019·Nutrients·Katherine RiveraAttilio Rigotti
Nov 25, 2020·International Journal of Molecular Sciences·Rosa LombardiAnna Ludovica Fracanzani
Jan 28, 2021·Antioxidants·Vittoria CammisottoSMiLe Group