PMID: 8942423Dec 1, 1996Paper

Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults

The American Journal of Clinical Nutrition
K C JengJ S Kuo

Abstract

The effect of supplementation with vitamins C and E on cytokine production of healthy adult volunteers was studied in a single-blind trial. Ten subjects in each group received daily vitamin C (1 g ascorbic acid), vitamin E (400 mg dl-alpha-tocopheryl acetate), or vitamins C and E for 28 d. Plasma concentrations of alpha-tocopherol, ascorbate, and lipid peroxides as well as the production of cytokines by peripheral blood mononuclear cells (PBMCs) were measured before, during, and at the end of the supplementation and 1 wk later. PBMCs were cultured in the presence of absence of lipopolysaccharide for 24 h. The interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) in the culture supernates were assayed by enzyme-linked immunosorbent assay methods. Production of IL-1 beta and TNF-alpha in the group supplemented with vitamins C and E was significantly higher (P < 0.05) than that of the groups given vitamin E or vitamin C alone. The enhancing effect of supplementation with a combination of vitamins E and C coincided with peak plasma alpha-tocopherol and ascorbate concentrations and the lowest plasma lipid peroxide concentrations (P < 0.05) on day 14. In addition, an in vitro experiment with PBMCs sh...Continue Reading

Citations

Apr 12, 2001·The British Journal of Nutrition·L G Darlington, T W Stone
Mar 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Jennifer M SacheckRonenn Roubenoff
Apr 25, 2007·Journal of Cellular Biochemistry·Eunsil HahmWang Jae Lee
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