Support for a proposed retinoid-processing protein complex in apical retinal pigment epithelium

Experimental Eye Research
Vera L BonilhaJohn W Crabb

Abstract

The interaction of cellular retinaldehyde-binding protein (CRALBP) with ERM (ezrin, radixin, moesin)-binding phosphoprotein 50 (EBP50) in retinal pigment epithelium (RPE) microsomes has led to the hypothesis that a retinoid-processing protein complex exists in apical RPE. Mouse RPE apical processes were isolated on wheat germ agglutinin-coated agarose beads. Proteomic analyses of the isolated apical RPE demonstrated the presence of CRALBP, EBP50, 11-cis-retinol dehydrogenase, cellular retinol-binding protein 1, and interphotoreceptor retinoid-binding protein. The results support the hypothesis that a visual cycle protein complex may serve in the localization and release of 11-cis-retinoid in the apical RPE.

References

Mar 15, 1994·Biochemistry·J C SaariN Noy
Dec 30, 1999·The Journal of Cell Biology·V L BonilhaE Rodriguez-Boulan
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Anthony BretscherRichard G Fehon
Aug 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·S ShenolikarE J Weinman
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·John W CrabbJoe G Hollyfield
Jan 22, 2003·The Journal of Biological Chemistry·Irina GolovlevaJohn W Crabb
Feb 26, 2003·Molecular & Cellular Proteomics : MCP·Karen A WestJohn W Crabb
Jan 28, 2004·Investigative Ophthalmology & Visual Science·Maria NawrotJohn C Saari

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Citations

Jun 16, 2012·PloS One·Xiaorong GuVera L Bonilha
Jan 8, 2011·Ophthalmology·Patrik SchatzThomas Rosenberg
Mar 5, 2016·American Journal of Ophthalmology·Monica B SevillaCynthia A Toth
Aug 30, 2008·Experimental Eye Research·Martin RudolfChristine A Curcio
Aug 27, 2005·Photochemistry and Photobiology·Małgorzata Rózanowska, Tadeusz Sarna
Jun 5, 2004·Progress in Retinal and Eye Research·T D Lamb, E N Pugh
Mar 21, 2006·Experimental Eye Research·Vera L BonilhaJoe G Hollyfield
Sep 30, 2014·Traffic·Nozomu Kono, Hiroyuki Arai
Jan 22, 2015·The Journal of Clinical Investigation·Yunlu XueVladimir J Kefalov
Jan 24, 2017·Progress in Retinal and Eye Research·Karina E GuziewiczGustavo D Aguirre
Sep 16, 2004·Molecular & Cellular Proteomics : MCP·Vera L BonilhaJoe G Hollyfield
Jul 1, 2005·Physiological Reviews·Olaf Strauss
Aug 15, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Seung Hee JeonYoung-Jung Roh
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Daniela IntartagliaIvan Conte

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