Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle.

FEBS Letters
Emily FlashmanJohanna Moolman-Smook

Abstract

Myosin-binding protein C (MyBPC) is proposed to take on a trimeric collar arrangement around the thick filament backbone in cardiac muscle, based on interactions between cardiac MyBPC domains C5 and C8. We have now determined, using yeast two-hybrid and in vitro binding assays, that the C5:C8 interaction is not dependent on the 28-residue cardiac-specific insert in C5. Furthermore, an interaction of similar affinity occurs between domains C5 and C8 of fast skeletal muscle MyBPC, but not between these domains of the slow skeletal muscle protein. These data have implications for the role and quaternary structure of MyBPC in skeletal muscle.

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Citations

Jan 12, 2012·The Journal of Biological Chemistry·Jack W HowarthPaul R Rosevear
Jan 25, 2011·The Journal of Biological Chemistry·Jeanne James, Jeffrey Robbins
May 1, 2009·Molecular Biology of the Cell·Maegen A AckermannAikaterini Kontrogianni-Konstantopoulos
Jan 29, 2014·Pflügers Archiv : European journal of physiology·Natosha L Finley, Tzvia I Cuperman
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Maegen A Ackermann, Aikaterini Kontrogianni-Konstantopoulos
Apr 17, 2010·Journal of Biomedicine & Biotechnology·Maegen A Ackermann, Aikaterini Kontrogianni-Konstantopoulos
Jun 19, 2012·Biophysics Reviews·Sakthivel Sadayappan, Pieter P de Tombe
Dec 3, 2014·Journal of Molecular Biology·Gerald Offer
Dec 18, 2009·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Sep 5, 2013·Journal of Molecular and Cellular Cardiology·Manish K GuptaJeffrey Robbins
Dec 8, 2009·Journal of Molecular and Cellular Cardiology·David Barefield, Sakthivel Sadayappan
May 17, 2008·Journal of Molecular and Cellular Cardiology·Walid SaberPeter VanBuren
Jan 9, 2019·Cardiovascular Drugs and Therapy·Thomas E KaierMichael Marber

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