Support for two increased vasopressinergic activities in depression at large and the differential effect of antidepressant treatment

Journal of Psychopharmacology
Jg GoekoopVm Wiegant

Abstract

Animal models of depression support a pathogenetic role for vasopressinergic activation involving increased arginine vasopressin (AVP) release and AVP receptor (V1b) synthesis. Evidence of this has been found particularly in patients with highly anxious-retarded (HAR) and above-normal AVP (ANA) depression. A general pathogenetic theory however predicts vasopressinergic activities to play a role in at least all major depressive disorders, and antidepressant (AD) treatment to be mediated by vasopressinergic reduction. We tested these hypotheses by re-analysing the data of 66 depressed patients; 27 with and 39 without AD treatment. The plasma AVP concentration and the AVP-cortisol correlation were used as presumed parameters of AVP release and pituitary V1b receptor function. A high AVP-cortisol correlation (r = 0.72; p < 0.001) was found in the non-AD group, and no correlation in the AD treatment group. AD treatment did not relate to plasma AVP concentration. The AVP-cortisol correlation in HAR and ANA depression was not explained by a low rate of AD treatment. These human data support the hypothesis of increased AVP release and receptor function as pathogenetic characteristics of major depression, and show selective normalizatio...Continue Reading

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Citations

Dec 29, 2011·Depression Research and Treatment·Jaap G Goekoop, Remco F P De Winter
Oct 15, 2013·Basic & Clinical Pharmacology & Toxicology·Aletta D KraneveldJohan Garssen
Jul 17, 2013·Journal of Affective Disorders·Jesper KroghMerete Nordentoft
May 18, 2016·Stress : the International Journal on the Biology of Stress·Péter CsikotaDóra Zelena
Apr 1, 2012·Therapeutic Advances in Psychopharmacology·Jaap G GoekoopVictor M Wiegant

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