Support of Tumor Endothelial Cells by Chemokine Receptors

Frontiers in Immunology
Nicole Salazar, Brian A Zabel

Abstract

Tumor-associated vascular endothelium comprises a specialized and diverse group of endothelial cells that, although not cancer themselves, are integral to cancer progression. Targeting the tumor vasculature can have significant efficacy in reducing tumor burden, although loss of efficacy due to acquisition of resistance mechanisms is common. Here we review mechanisms by which tumor endothelial cells (TEC) utilize chemokine receptors to support tumor progression. We illustrate how chemokine receptors support and may serve as functional markers of the diverse TEC population. We focus on ACKR1 (DARC), ACKR3 (CXCR7), CXCR4, and CCR2, as these are the best studied chemokine receptors in TEC; and suggest that targeting these receptors on the tumor vasculature may prove efficacious in slowing or reversing tumor growth. We also mention CXCR2 and CXCR3 as important mediators or tumor angiogenesis, given their distinct roles with angiogenic and angiostatic chemokines, respectively.

References

Nov 10, 1995·The Journal of Biological Chemistry·R M StrieterD Marriott
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L AddisonR M Strieter
Feb 6, 2002·The Journal of Clinical Investigation·Morayma ReyesCatherine M Verfaillie
Mar 1, 2002·British Journal of Cancer·E PassalidouF Pezzella
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P KeaneRobert M Strieter
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Jul 13, 2004·Seminars in Cancer Biology·Fran Balkwill
Jul 25, 2006·Nature Medicine·Sucharita BandyopadhyayKounosuke Watabe
Aug 31, 2006·The Journal of Experimental Medicine·Jennifer M BurnsThomas J Schall
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jun FengWilliam C Aird
Jun 15, 2007·Biochemical and Biophysical Research Communications·Zhongxing LiangHyunsuk Shim
Jun 15, 2007·Cancer Cell·Steven SeamanBrad St Croix
Feb 13, 2008·Cell·Bijan BoldajipourErez Raz
Jun 27, 2008·Cancer Letters·Jo VandercappellenSofie Struyf
Feb 26, 2009·British Journal of Cancer·J A NagyH F Dvorak
Jul 31, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian A ZabelThomas J Schall
May 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gong YangJinsong Liu
Sep 28, 2010·Biochemical and Biophysical Research Communications·Hongbao LiuXiaohui Tian
Oct 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert D BerahovichThomas J Schall
Nov 3, 2010·Experimental Cell Research·Ellen C KeeleyRobert M Strieter
Nov 26, 2010·Nature·Rong WangViviane Tabar
Feb 9, 2011·The Journal of Experimental Medicine·Lillian Cruz-OrengoRobyn S Klein
Feb 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan G DudaRakesh K Jain
Jun 16, 2011·Molecular Cancer·Brian A ZabelThomas J Schall
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·William C Aird
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Andrew C Dudley
Apr 11, 2012·Molecular Immunology·Galina ObmolovaGary L Gilliland
Jun 12, 2012·Cell·Rakesh K Jain, Peter Carmeliet
Jun 16, 2012·Immunology Letters·G J GrahamM Thelen

❮ Previous
Next ❯

Citations

Apr 9, 2020·Cell Communication and Signaling : CCS·Roghayyeh BaghbanPeyman Zare
Nov 23, 2019·Cell and Tissue Research·Morteza HeidarzadehReza Rahbarghazi
Jun 26, 2020·Frontiers in Immunology·Dina MoreinAdit Ben-Baruch
Sep 21, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Reena P ThomasLawrence D Recht
Jan 21, 2021·Pharmaceutics·Adriana G Quiroz-ReyesElsa N Garza-Treviño
Sep 22, 2020·Annual Review of Pharmacology and Toxicology·Martine J SmitFederico Mayor
Mar 16, 2021·Critical Reviews in Oncology/hematology·RamaRao MallaGanji Purnachandra Nagaraju
Mar 19, 2021·Journal of Molecular and Cellular Cardiology·Paweł UruskiKrzysztof Książek
Mar 26, 2021·Advanced Healthcare Materials·Özlem ŞenGianni Ciofani
May 8, 2021·Cancer Metastasis Reviews·Sugandha Saxena, Rakesh K Singh
Jun 7, 2021·Trends in Cancer·Bárbara B MendesJoão Conde

❮ Previous
Next ❯

Methods Mentioned

BETA
scRNA-seq
xenografts
xenograft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.