PMID: 7757418Nov 1, 1994Paper

Support studies for installing the phosphodiester residues of the Thy-1 glycoprotein membrane anchor

Bioorganic & Medicinal Chemistry
A S Campbell, B Fraser-Reid


Support studies for late-stage installation of the three different types of phosphodiesters found in the rat brain Thy-1 glycoprotein membrane anchor are described. The strategy is geared towards optimizing convergency and the development of chemoselective procedures including deprotection, phosphorylation, esterification and cysteinylation has been investigated. Some of these procedures are being designed for oligosaccharides containing several unprotected hydroxy groups.


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