Support vector machine classification of major depressive disorder using diffusion-weighted neuroimaging and graph theory

Frontiers in Psychiatry
Matthew D SacchetIan H Gotlib

Abstract

Recently, there has been considerable interest in understanding brain networks in major depressive disorder (MDD). Neural pathways can be tracked in the living brain using diffusion-weighted imaging (DWI); graph theory can then be used to study properties of the resulting fiber networks. To date, global abnormalities have not been reported in tractography-based graph metrics in MDD, so we used a machine learning approach based on "support vector machines" to differentiate depressed from healthy individuals based on multiple brain network properties. We also assessed how important specific graph metrics were for this differentiation. Finally, we conducted a local graph analysis to identify abnormal connectivity at specific nodes of the network. We were able to classify depression using whole-brain graph metrics. Small-worldness was the most useful graph metric for classification. The right pars orbitalis, right inferior parietal cortex, and left rostral anterior cingulate all showed abnormal network connectivity in MDD. This is the first use of structural global graph metrics to classify depressed individuals. These findings highlight the importance of future research to understand network properties in depression across imaging...Continue Reading

References

Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·H S Mayberg
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Apr 26, 2001·Journal of Clinical and Experimental Neuropsychology·M Liotti, H S Mayberg
Apr 18, 2002·Biological Psychiatry·J Douglas BremnerDennis S Charney
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Feb 13, 2004·Biological Psychiatry·Acioly L T LacerdaJair C Soares
Aug 25, 2004·NeuroImage·K J Friston, J Ashburner
Jan 18, 2005·Journal of Neuroscience Methods·Babak A ArdekaniJay Nierenberg
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher J HoneyOlaf Sporns
Jul 21, 2009·Biological Psychiatry·Claire E SextonKlaus P Ebmeier
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Jun 8, 2010·Psychophysiology·Jennifer L StewartJohn J B Allen
Dec 15, 2010·Biological Psychiatry·Clement HamaniAndres M Lozano
Mar 8, 2011·Medical Image Analysis·Iman AganjGuillermo Sapiro
Apr 5, 2011·NeuroImage·Mikail Rubinov, Olaf Sporns
Apr 14, 2011·Annals of the New York Academy of Sciences·Benjamin J Levy, Anthony D Wagner
Feb 7, 2012·Neuroscience and Biobehavioral Reviews·Graziella OrrùAndrea Mechelli
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng BaiZhijun Zhang
Jun 14, 2012·Journal of Psychiatry & Neuroscience : JPN·Yi LiaoQiyong Gong
Aug 4, 2012·Journal of Affective Disorders·L WangJ Lagopoulos
Jan 9, 2013·Current Opinion in Neurobiology·Olaf Sporns
Apr 23, 2013·Biological Psychiatry·Manpreet K SinghIan H Gotlib
Sep 10, 2013·Neuroinformatics·Benson MwangiJair C Soares
Oct 29, 2013·Brain : a Journal of Neurology·Chun MengChristian Sorg
Nov 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Olusola AjiloreAnand Kumar
Nov 16, 2013·Trends in Cognitive Sciences·Martijn P van den Heuvel, Olaf Sporns

❮ Previous
Next ❯

Citations

Mar 26, 2016·Frontiers in Systems Neuroscience·Aaron S Heller
Apr 5, 2016·NeuroImage·George GiffordPhilip McGuire
May 10, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marzieh ZareApril A Benasich
Jun 17, 2016·Expert Review of Neurotherapeutics·Matthew D Sacchet, Ian H Gotlib
May 31, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew D SacchetTony T Yang
Feb 24, 2017·Nature Neuroscience·Danielle S Bassett, Olaf Sporns
Jun 27, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku Kim, Kyoung-Sae Na
Aug 18, 2017·Methods of Information in Medicine·Marcos A Mouriño-GarcíaLuis E Anido-Rifón
Aug 24, 2018·CNS Neuroscience & Therapeutics·Shuang GaoJing Sui
Apr 5, 2018·CNS Spectrums·Andrea Mendez-TorrijosAndreas Hess
May 7, 2020·Human Brain Mapping·Barnaly Rashid, Vince Calhoun
Apr 5, 2020·International Journal of Molecular Sciences·Seung-Gul Kang, Seo-Eun Cho
Jul 11, 2020·Medical & Biological Engineering & Computing·Jiang ZhangShasha Li
Dec 17, 2020·Neurological Research and Practice·Jannik PrasuhnNorbert Brüggemann
Oct 16, 2020·The International Journal of Neuroscience·Rutvi Prajapati, Isaac Arnold Emerson
Jul 8, 2021·Behaviour Research and Therapy·Idan M AderkaThröstur Björgvinsson

❮ Previous
Next ❯

Software Mentioned

FreeSurfer
Brain Connectivity Toolbox [ BCT
MATLAB
FMRIB Software Library FSL )

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.