Supported lipid bilayer platforms to probe cell mechanobiology

Biochimica Et Biophysica Acta. Biomembranes
Roxanne Glazier, Khalid Salaita

Abstract

Mammalian and bacterial cells sense and exert mechanical forces through the process of mechanotransduction, which interconverts biochemical and physical signals. This is especially important in contact-dependent signaling, where ligand-receptor binding occurs at cell-cell or cell-ECM junctions. By virtue of occurring within these specialized junctions, receptors engaged in contact-dependent signaling undergo oligomerization and coupling with the cytoskeleton as part of their signaling mechanisms. While our ability to measure and map biochemical signaling within cell junctions has advanced over the past decades, physical cues remain difficult to map in space and time. Recently, supported lipid bilayer (SLB) technologies have emerged as a flexible platform to mimic and perturb cell-cell and cell-ECM junctions, allowing one to study membrane receptor mechanotransduction. Changing the lipid composition and underlying substrate tunes bilayer fluidity, and lipid and ligand micro- and nano-patterning spatially control positioning and clustering of receptors. Patterning metal gridlines within SLBs confines lipid mobility and introduces mechanical resistance. Here we review fundamental SLB mechanics and how SLBs can be engineered as tun...Continue Reading

Citations

Nov 16, 2018·Angewandte Chemie·Ann-Kathrin Schneider, Christof M Niemeyer
Dec 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yun ZhangKhalid Salaita
Jan 3, 2020·Journal of Biomedical Materials Research. Part a·Johanna F M VerstappenRichard T Jaspers
Jun 9, 2019·Nature Protocols·Abdul Rahim FerhanNam-Joon Cho
Jul 16, 2019·The Journal of Chemical Physics·Takuhiro Otosu, Shoichi Yamaguchi
Jun 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Yu LiuMichael Hirtz
Feb 21, 2021·Methods : a Companion to Methods in Enzymology·Siddhartha Banerjee, Yuri L Lyubchenko
Jun 24, 2018·Biochimica Et Biophysica Acta. Biomembranes·Kent Shilts, Christoph A Naumann
Oct 20, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Xinyuan ZhangKeyue Shen
May 6, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Anastasia SvetlovaAndreas Offenhäusser
Aug 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Kanokporn ChattrakunGavin M King
Sep 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Luke Ashley CliftonMaximilian W A Skoda
Jan 20, 2021·ACS Biomaterials Science & Engineering·Johana UribeSusan Daniel
Oct 27, 2018·Analytical Chemistry·Pieter E OomenAndrew G Ewing
Nov 21, 2019·Nano Letters·Swathi SudhakarErik Schäffer
Jan 9, 2021·ACS Applied Materials & Interfaces·Roxanne GlazierKhalid Salaita
Oct 23, 2021·ACS Applied Materials & Interfaces·Eider Berganza, Michael Hirtz
Nov 23, 2021·ACS Biomaterials Science & Engineering·Johana UribeSusan Daniel
Nov 26, 2021·Advanced Materials·Fangyuan XiuTibor Kudernac

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Integrative Biology : Quantitative Biosciences From Nano to Macro
Allen P LiuSapun H Parekh
Cellular and Molecular Life Sciences : CMLS
Floor Twiss, Johan de Rooij
© 2022 Meta ULC. All rights reserved