Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration

BioResearch Open Access
Erica SilvestrisYves Ménézo

Abstract

Environmental endocrine disrupting chemicals (EDCs), including bisphenol A (BPA), induce DNA methylation errors and oxidative stress, and alter fertility. Animal studies have demonstrated that supporting the one-carbon cycle (1-CC) with appropriate dietary supplements can reduce the effects of EDCs. Anti-Mullerian hormone (AMH), a marker of ovarian functionality, has been tested in subfertile female patients, to control this hypothesis in humans. Fifty-five women with a history of 3-7 years of infertility, with at least two assisted reproductive technology (ART) treatment failures, and low serum levels of AMH were enrolled in the study. Before starting any further ART treatment, they were tested for AMH and for follicular count. A urinary control of BPA was proposed. Then a support of the 1-CC, already tested in other clinical studies, was initiated and continued for 4 months. At the end of this period, antral follicle count and serum AMH levels were re-evaluated. The AMH levels before and after treatment were compared using the Wilcoxon test (nonparametric test, non-Gaussian population). Out of the 55 patients, 35 accepted a BPA dosage in the urine. No correlation was found between BPA and serum AMH concentrations. Forty-nine ...Continue Reading

References

Aug 7, 2002·The Journal of Nutrition·Craig A CooneyGeorge L Wolff
May 26, 2004·Lancet·Cristina Joana MarquesAlberto Barros
Jul 20, 2007·Human Molecular Genetics·Hisato KobayashiTakahiro Arima
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
Jul 31, 2008·Human Reproduction·Jolanda C BoxmeerNick S Macklon
Aug 25, 2010·Journal of Cellular and Molecular Medicine·Andriy SukhodubAleksandar Jovanović
Sep 18, 2010·Human Reproduction·Qingyou DuAleksandar Jovanović
Mar 13, 2012·Annual Review of Biochemistry·Howard Cedar, Yehudit Bergman
Feb 23, 2013·Journal of Assisted Reproduction and Genetics·Yves MénézoKay Elder
Mar 5, 2013·Environmental Health Perspectives·Allan H Smith
Jul 31, 2014·Reproductive Biology and Endocrinology : RB&E·Maurizio DattiloYves Menezo
Jan 13, 2015·Biochimica Et Biophysica Acta·Khaja Shameem Mohammed AbdulAleksandar Jovanović
Jan 30, 2015·PloS One·Natalia M GrindlerAmber R Cooper
Apr 18, 2015·International Journal of Cardiology·Khaja Shameem Mohammed AbdulAleksandar Jovanović
Sep 12, 2015·Fertility and Sterility·Kenneth I AstonDouglas T Carrell
Oct 16, 2016·Reproductive Biomedicine Online·Yves J R MenezoKay Elder

❮ Previous
Next ❯

Citations

Jun 9, 2018·Journal of Assisted Reproduction and Genetics·Edouard J ServyYves J R Menezo
Jun 25, 2019·Frontiers in Endocrinology·Erica SilvestrisRaffaele Palmirotta
May 26, 2021·Journal of Assisted Reproduction and Genetics·Xinrui WangXin Feng

❮ Previous
Next ❯

Methods Mentioned

BETA
Solid Phase Extraction
environmental stresses

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.