Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss

Probiotics and Antimicrobial Proteins
Nima Montazeri-NajafabadyAhmad Gholami

Abstract

Osteoporosis is a major health problem that occurs as a result of an imbalance between bone formation and bone resorption. Different approaches have been established for treating osteoporosis. Recently, because of their health benefits and also low adverse reaction, probiotics have been receiving considerable attention. In this study, we compared the effectiveness of five probiotic strains, Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei, Bifidobacterium longum, and Bacillus coagulans, in protecting rats from ovariectomized (OVX)-induced bone loss. Forty-nine adult female Sprague-Dawley rats were allocated into seven groups as follows: group 1, control; group 2, OVX; group 3, OVX + Lactobacillus acidophilus; group 4, OVX + Lactobacillus casei; group 5, OVX + Bacillus coagulans; group 6, OVX + Bifidobacterium longum; and group 7, OVX + Lactobacillus reuteri. Probiotics were fed to OVX groups at the concentration of (1 × 109 CFU/ml/day) for 4 weeks. Then, biochemical parameters, including vitamin D, calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP), were assessed. Dual-energy X-ray absorptiometry (DEXA) scans were used that assess bone mineral density (BMD), bone marrow concentration (BMC), and ar...Continue Reading

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Citations

Dec 31, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan D SchepperLaura R McCabe
Nov 22, 2019·Current Osteoporosis Reports·Hanel Sadie-Van Gijsen
Oct 13, 2020·Frontiers in Microbiology·Maria AponteMahtab Shoukat
Jan 26, 2021·Nutrition Reviews·Natalia Wawrzyniak, Joanna Suliburska
Dec 11, 2020·BioMed Research International·Aein AzarangAhmad Gholami
Dec 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Seyyed Mojtaba MousaviSargol Mazraedoost
Feb 2, 2021·American Journal of Physiology. Endocrinology and Metabolism·Claes OhlssonKlara Sjögren
May 30, 2021·BMC Complementary Medicine and Therapies·Nima Montazeri-NajafabadyAhmad Gholami
Jun 25, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mahsa MoazenMohammad Fararouei
Jun 13, 2021·Genomics, Proteomics & Bioinformatics·Zhuye JieHuijue Jia
Aug 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Hanieh MalmirShirin Hasani-Ranjbar
Aug 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Seyyed Mojtaba MousaviNelson Pynadathu Rumjit

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