Supportive therapy in gastroenteropancreatic neuroendocrine tumors: Often forgotten but important

Reviews in Endocrine & Metabolic Disorders
Xi-Feng JinChristoph J Auernhammer

Abstract

Neuroendocrine tumors (NETs) are a group of rare and heterogeneous malignancies that can develop in various organs. A significant number of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is functionally active and presents with symptoms related to the secretion of biologically active substances, leading to the development of distinct clinical syndromes. There are various therapeutic approaches for GEP-NETs, including curative surgery, palliative surgery, local-ablative and loco-regional therapies as well as systemic therapeutic options including peptide receptor radionuclide therapy, cytotoxic therapy, and molecularly targeted therapies. Specific supportive therapy of patients with NETs includes management or prevention of hormone-related clinical syndromes and paraneoplastic states. Supportive therapy plays a key role in NET treatment. Supportive therapy includes debulking surgery and interventional radiologic techniques to reduce tumour bulk or load, as well as systemic medical treatment options to manage or prevent hypersecretion syndromes and treatment-related side effects. Supportive therapies are a type of of comprehensive treatment addressing the patient as a whole person throughout the process of NET treatment...Continue Reading

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Citations

May 21, 2020·Nutrients·Jakub PobłockiMałgorzata Szczuko
Sep 30, 2018·Reviews in Endocrine & Metabolic Disorders·Barbara AltieriAntongiulio Faggiano
Oct 26, 2018·Reviews in Endocrine & Metabolic Disorders·Christian A Koch, S Petersenn
Jul 10, 2021·Cancer Treatment Reviews·Stefano PartelliPhilip Poortmans

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