Abstract
An exaggerated acoustic startle reflex (ASR) is a clinical indicator of anxiety disorders, such as post-traumatic stress disorder (PTSD). Given the prevalence of PTSD following traumatic brain injury (TBI), we studied the effects of TBI on ASR. Adult Sprague Dawley rats exposed to moderate controlled cortical impact injury model of TBI displayed suppression of ASR intensity and sensitivity. As patients with PTSD have been shown to display hyperactive startle responses, the present discrepant observation of TBI-induced suppression of ASR has clinical implications, in that the reduced, instead of elevated, startle response in patients with comorbid TBI/PTSD could be owing to a masking effect of TBI.
References
Jan 1, 1996·The American Journal of Psychiatry·C A MorganD S Charney
Jul 1, 1996·Neurobiology of Learning and Memory·P K Pilz, H U Schnitzler
Apr 15, 1996·Brain Research·J L WileyR J Hamm
Apr 2, 1998·Physiology & Behavior·W P Jordan, L H Poore
Aug 27, 1999·Progress in Neurobiology·M Koch
Oct 28, 2009·The Journal of Head Trauma Rehabilitation·Rochelle Whelan-GoodinsonFiona Grant
Mar 18, 2010·The Journal of Head Trauma Rehabilitation·John D CorriganJean A Langlois Orman
Dec 21, 2010·Cognitive Behaviour Therapy·Gordon J G Asmundson, R Nicholas Carleton
Jan 5, 2011·Archives of General Psychiatry·Melissa A PolusnyPaul Thuras
Sep 8, 2011·Depression and Anxiety·Ebony M GloverTanja Jovanovic
Jun 30, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Jennifer J VasterlingMolly Franz
Jun 6, 2014·Journal of Psychopharmacology·Verity PinkneyMatthew Garner
Jun 19, 2014·Journal of Neuroscience Research·Hao LuoJinsheng Zhang
Nov 21, 2014·Journal of Neurotrauma·Kevin PangRichard Servatius
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hideaki InagakiYuji Mori
May 15, 2015·Brain Imaging and Behavior·Katherine M HelmickSidney R Hinds
Jan 19, 2016·CNS Neuroscience & Therapeutics·Mibel M PabónCesar V Borlongan
Jun 22, 2016·Critical Care : the Official Journal of the Critical Care Forum·Nino Stocchetti, Elisa R Zanier
Sep 23, 2016·Neurosurgery·Nancy CarneyJamshid Ghajar
Dec 22, 2016·JAMA Psychiatry·Richard A BryantDusan Hadzi-Pavlovic
May 1, 2017·Neuropharmacology·Mahsa Moaddab, Joanna Dabrowska