Suppressed acoustic startle response in traumatic brain injury masks post-traumatic stress disorder hyper-responsivity

Neuroreport
Grant M LiskaCesario V Borlongan

Abstract

An exaggerated acoustic startle reflex (ASR) is a clinical indicator of anxiety disorders, such as post-traumatic stress disorder (PTSD). Given the prevalence of PTSD following traumatic brain injury (TBI), we studied the effects of TBI on ASR. Adult Sprague Dawley rats exposed to moderate controlled cortical impact injury model of TBI displayed suppression of ASR intensity and sensitivity. As patients with PTSD have been shown to display hyperactive startle responses, the present discrepant observation of TBI-induced suppression of ASR has clinical implications, in that the reduced, instead of elevated, startle response in patients with comorbid TBI/PTSD could be owing to a masking effect of TBI.

References

Jan 1, 1996·The American Journal of Psychiatry·C A MorganD S Charney
Aug 27, 1999·Progress in Neurobiology·M Koch
Oct 28, 2009·The Journal of Head Trauma Rehabilitation·Rochelle Whelan-GoodinsonFiona Grant
Mar 18, 2010·The Journal of Head Trauma Rehabilitation·John D CorriganJean A Langlois Orman
Dec 21, 2010·Cognitive Behaviour Therapy·Gordon J G Asmundson, R Nicholas Carleton
Jun 30, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Jennifer J VasterlingMolly Franz
Jun 6, 2014·Journal of Psychopharmacology·Verity PinkneyMatthew Garner
Jun 19, 2014·Journal of Neuroscience Research·Hao LuoJinsheng Zhang
Nov 21, 2014·Journal of Neurotrauma·Kevin PangRichard Servatius
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hideaki InagakiYuji Mori
May 15, 2015·Brain Imaging and Behavior·Katherine M HelmickSidney R Hinds
Jun 22, 2016·Critical Care : the Official Journal of the Critical Care Forum·Nino Stocchetti, Elisa R Zanier
Sep 23, 2016·Neurosurgery·Nancy CarneyJamshid Ghajar

❮ Previous
Next ❯

Citations

Jan 14, 2021·Scientific Reports·Carolina BeppiStefan Yu Bögli
May 31, 2021·Seizure : the Journal of the British Epilepsy Association·Cesar E Santana-GomezBrian K Rundle

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

© 2022 Meta ULC. All rights reserved