Suppressed dopaminergic activity and water-sodium handling in the kidneys at the prehypertensive stage of essential hypertension

Journal of Autonomic Pharmacology
O Iimura, K Shimamoto

Abstract

1. In this study, the question of whether the suppression of the renal dopaminergic system is primary or not was investigated. 2. Renal dopaminergic activity was compared between young healthy normotensive subjects without a family history of hypertension (FH(-] and those with a family history of hypertension (FH(+]. 3. A significant decrease in urinary free dopamine excretion was noted, and the responses of urine volume, urinary sodium excretion, and fractional excretion of sodium to infused dopamine were significantly augmented in FH(+). In addition, a normal level of l-dopa delivery at the renal proximal tubules and a significant reduction in the conversion of l-dopa to dopamine in the kidney were found in FH(+). 4. These findings suggest that renal dopaminergic activity is already suppressed at the prehypertensive stage, and that the reduction in the conversion of l-dopa to dopamine in the proximal tubules may contribute to the attenuation of renal dopaminergic activity in FH(+).

References

Sep 1, 1979·Japanese Circulation Journal·O IimuraM Miyahara
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·O Iimura
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·K AokiT Sakamoto

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Citations

Jul 16, 2008·Current Hypertension Reports·Anees Ahmad Banday, Mustafa F Lokhandwala
Feb 26, 2000·Acta Physiologica Scandinavica·U HoltbäckA Aperia
Jun 1, 1992·Pharmacology & Toxicology·C Chen, M F Lokhandwala
May 10, 2000·Clinical and Experimental Hypertension : CHE·P Soares-da-SilvaM Cerqueira-Gomes
Feb 19, 2004·American Journal of Physiology. Renal Physiology·Rui PedrosaP Soares-da-Silva
Jul 22, 2004·American Journal of Physiology. Renal Physiology·Rui PedrosaPatrício Soares-da-Silva
Aug 27, 1998·Hypertension·T Hussain, M F Lokhandwala
Mar 15, 1993·Annals of the New York Academy of Sciences·O Iimura, K Shimamoto
Dec 16, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sónia FragaPatrício Soares-da-Silva
Feb 11, 1998·Physiological Reviews·C MissaleM G Caron
Feb 4, 2003·Experimental Biology and Medicine·Tahir Hussain, Mustafa F Lokhandwala
Mar 5, 1998·The American Journal of Physiology·P Soares-Da-SilvaM A Vieira-Coelho

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