PMID: 7540397Jan 1, 1995Paper

Suppressed fibrinolysis after administration of low-dose aprotinin: reduced level of plasmin-alpha2-plasmin inhibitor complexes and postoperative blood loss

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
P MastrorobertoA R Marchese

Abstract

Various clinical investigation have shown that aprotinin therapy reduces bleeding after open-heart operations. In this study low-dose aprotinin, 30,000 KIU/kg in the cardiopulmonary bypass (CPB) priming volume and 7,500 KIU/kg intravenously each hour during CPB, was used in ten patients undergoing primary myocardial revascularization or surgery for valvular diseases. Another ten patients served as controls. Blood loss, platelet count and plasma levels of hemoglobin, antithrombin III, fibrinogen, fibrinogen degradation products (FDP), total plasmin inhibitor and alpha2-plasmin inhibitor-plasmin complexes were evaluated at nine preoperative, intraoperative and postoperative points. Intraoperative and postoperative blood loss was significantly reduced in the aprotinin group. There was no significant difference between the two groups in platelet count and levels of hemoglobin and antithrombin III. A significant increase in FDP during CPB in the control group indicated hyperfibrinolysis. The levels of plasmin inhibitor were significantly reduced during CPB in the control group. The alpha 2-plasmin inhibitor-plasma complex levels, indicating the plasmin activity, were significantly reduced in the aprotinin group. These results confir...Continue Reading

Citations

Mar 27, 1998·American Journal of Surgery·Y OzoğulI Sayek
Oct 13, 1998·The Annals of Thoracic Surgery·M MisfeldH H Sievers
Jul 31, 2008·International Journal of Laboratory Hematology·T W Stief
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P P PunjabiK M Taylor
Mar 13, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Frank KuepperAlbrecht Wiebalck
Nov 1, 1996·The Annals of Thoracic Surgery·E M BoyleB D Spiess
Jul 9, 2004·Orthopedics·Jerrold H Levy, Edward Sypniewski

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