Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice

Scientific Reports
Ryu-Ichiro HataMasaru Taniguchi

Abstract

Cancer progression involves carcinogenesis, an increase in tumour size, and metastasis. Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on these processes by using CXCL14/BRAK (CXCL14) transgenic (Tg) mice. The rate of AOM/DSS-induced colorectal carcinogenesis in these mice was significantly lower compared with that for isogenic wild type C57BL/6 (Wt) mice. When tumour cells were injected into these mice, the size of the tumours that developed and the number of metastatic nodules in the lungs of the animals were always significantly lower in the Tg mice than in the Wt ones. Injection of anti-asialo-GM1 antibodies to the mice before and after injection of tumour cells attenuated the suppressing effects of CXCL14 on the tumor growth and metastasis, suggesting that NK cell activity played an important role during CXCL14-mediated suppression of tumour growth and metastasis. The importance of NK cells on the metastasis was also supported when CXCL14 was expressed in B16 melanoma cells. Further, the survival rates after tumour cell injection were significantly increased for the Tg mice. As these Tg mice showed no obvious abnormality, we propose that CXCL14 to be a promising molecular target for canc...Continue Reading

References

Apr 1, 1993·Trends in Genetics : TIG·B Vogelstein, K W Kinzler
Mar 2, 1999·Biochemical and Biophysical Research Communications·R HromasY H Hou
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jun 15, 2000·The American Journal of Pathology·M J FrederickG L Clayman
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Oct 2, 2003·British Journal of Cancer·M V Blagosklonny
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Nov 19, 2004·Cancer Research·Thomas D ShellenbergerMitchell J Frederick
Jan 15, 2005·The Prostate·Steven R SchwarzeDavid F Jarrard
Feb 16, 2006·Journal of Leukocyte Biology·Takashi Kakinuma, Sam T Hwang
Feb 21, 2006·Cancer Research·Kazuo YasumotoIkuo Saiki
Jun 30, 2006·Cancer Science·Ken-ichiro SeinoMasaru Taniguchi
Aug 4, 2006·Biochemical and Biophysical Research Communications·Shigeyuki OzawaRyu-Ichiro Hata
Sep 23, 2006·Nature Reviews. Cancer·Mario E Lacouture
Oct 13, 2006·Nature Reviews. Cancer·Eva Szabo
Jan 5, 2007·Genome Biology·Albert ZlotnikHisayuki Nomiyama
Jul 17, 2007·Cancer Letters·Dayanidhi RamanAnn Richmond
Oct 3, 2007·Cancer Research·Yanming ZhaoVivek M Rangnekar
Nov 28, 2008·Carcinogenesis·Daniel W RosenbergTakuji Tanaka
Feb 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin AugstenArne Ostman
Jun 25, 2009·Nature Reviews. Cancer·Thomas G Cotter
Sep 24, 2009·Cancer Research·Boryana Konstantinova PopivanovaNaofumi Mukaida
Mar 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Limo ChenShuhua Han
Mar 25, 2010·Transgenic Research·Kazuhito IzukuriRyu-Ichiro Hata
Mar 10, 2012·Cell·Isabel Garcia-CaoPier Paolo Pandolfi
Nov 16, 2012·Nature Reviews. Cancer·Asad UmarPeter Greenwald
Apr 20, 2013·American Journal of Respiratory Cell and Molecular Biology·Renat ShaykhievRonald G Crystal
May 15, 2013·FEBS Letters·Kosuke TanegashimaTakahiko Hara
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Nov 28, 2013·Carcinogenesis·Daniela HirschTimo Gaiser

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Citations

Apr 4, 2015·Journal of Immunoassay & Immunochemistry·Monica NeaguCaterina Longo
Sep 12, 2018·The Journal of Clinical Investigation·Yingying WangJianhua Wang
Mar 27, 2020·Molecular Carcinogenesis·Joseph A WestrichDohun Pyeon
Dec 29, 2018·International Journal of Molecular Sciences·Elisabetta MarcuzziBianca Calì
Apr 25, 2019·International Journal of Molecular Sciences·Xiao-Yan YangRyu-Ichiro Hata
Sep 23, 2020·Journal for Immunotherapy of Cancer·Anuraag ParikhSidharth V Puram
Oct 29, 2020·Journal of Receptor and Signal Transduction Research·Jianqiang BiChengzhen Xu
Oct 30, 2020·International Journal of Molecular Sciences·Jan KorbeckiPiotr Dzięgiel
Apr 7, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qian ZhangShengtao Zhou
May 2, 2021·International Immunopharmacology·Arezoo Gowhari ShabgahJamshid Gholizadeh Navashenaq
Jun 3, 2021·International Journal of Molecular Sciences·Alejandro Álvarez-ArtimeJuan Carlos Mayo
Jul 16, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rina IwaseKosuke Tanegashima

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Methods Mentioned

BETA
transgenic
FACS
dissection

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