Suppressing Brownian motion of individual biomolecules in solution

Proceedings of the National Academy of Sciences of the United States of America
Adam E Cohen, W E Moerner

Abstract

Single biomolecules in free solution have long been of interest for detailed study by optical methods, but Brownian motion prevents the observation of one single molecule for extended periods. We have used an anti-Brownian electrokinetic (ABEL) trap to trap individual protein molecules in free solution, under ambient conditions, without requiring any attachment to beads or surfaces. We also demonstrate trapping and manipulation of single virus particles, lipid vesicles, and fluorescent semiconductor nanocrystals.

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Citations

Jun 23, 2009·Analytical and Bioanalytical Chemistry·Nan LiEdward S Yeung
Apr 13, 2010·Applied Physics. B, Lasers and Optics·Q Wang, W E Moerner
Jun 19, 2010·Analytical Chemistry·Sabrina R LeslieAdam E Cohen
Nov 3, 2010·Analytical Chemistry·Yuji IshitsukaTaekjip Ha
May 24, 2012·Accounts of Chemical Research·Quan WangW E Moerner
Jun 14, 2012·Journal of the American Chemical Society·Kiyoto KamagataSatoshi Takahashi
Sep 21, 2011·The Journal of Physical Chemistry. B·Samuel BockenhauerW E Moerner
May 21, 2013·Nano Letters·Melikhan Tanyeri, Charles M Schroeder
Jul 26, 2013·Nano Letters·Chad RoppEdo Waks
Jul 14, 2010·Nature Chemistry·Randall H Goldsmith, W E Moerner
Dec 3, 2010·Nature Chemistry·Peter Dedecker, Johan Hofkens
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Apr 25, 2013·Physical Chemistry Chemical Physics : PCCP·Armin HoffmannMichael T Woodside
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yan JiangW E Moerner
Oct 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Taekjip Ha, Sua Myong
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Randall H GoldsmithW E Moerner
Jun 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Peter JönssonDavid Klenerman
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Jan 1, 2012·Biomicrofluidics·Fangfang RenShengnian Wang
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adam E Cohen, W E Moerner
Aug 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·W E Moerner
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ophir Flomenbom, Robert J Silbey
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