PMID: 8584982Jan 1, 1995Paper

Suppressing effect of WR-2721 on micronuclei induced by cyclophosphamide in mice

Teratogenesis, Carcinogenesis, and Mutagenesis
A Czyzewska, L Mazur

Abstract

The effect of WR-2721 against cyclophosphamide-induced clastogenicity was studied using the in vivo micronucleus assay. The frequency of micronuclei in polychromatic erythrocytes in the peripheral blood of mice treated with WR-2721 and cyclophosphamide (CP), each of the compounds at a dose of 200 mg/kg body weight, was evaluated during the 15-day period. The suppressing effect of WR-2721, given 30 min prior to cyclophosphamide administration, on micronuclei induced by the alkylating agent was demonstrated. The number of micronuclei was increased on day 1 after CP application and declined thereafter with the frequency of micronucleated polychromatic erythrocytes remaining lower in WR-2721 pre-treated mice. The modulatory effect of WR-2721 on the clastogenic activity of cyclophosphamide in the erythropoietic system by the mouse micronucleus test was shown.

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Citations

Dec 16, 1998·Mutation Research·A GiriS B Prasad
Jan 29, 2002·Environmental and Molecular Mutagenesis·Marcelo de Campos NebelMarcela González-Cid
Jul 27, 2010·European Journal of Pharmacology·Surya Bali PrasadBonnie M Nicol
May 16, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B M Nicol, S B Prasad

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