Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model

International Journal of Cancer. Journal International Du Cancer
Hiroshi KobayashiT Terao

Abstract

The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human ovarian cancer HRA cells were investigated in i.v., s.c. and i.p. injection models in mice. Seven groups of female C57BL/6 or nude mice were fed a basal diet (control group) or the basal diet supplemented with KTI or BBI (5, 15, or 50 g/kg). Here we show that, in an in vivo spontaneous metastasis assay, the diet supplementation with KTI (15 and 50 g/kg), but not with BBI, for 28 days immediately after s.c. tumor cell inoculation significantly inhibited the formation of lung metastasis in C57BL/6 mice in a dose-dependent manner. The inhibition of lung metastasis was not due to direct antitumor effects of KTI. In an in vivo experimental metastasis assay, the diet supplementation with KTI or BBI for 21 days after i.v. tumor cell inoculation did not reduce the number of lung tumor colonies. In addition, KTI (15 or 50 g/kg) treatment in a peritoneal disseminated metastasis model of HRA cells resulted in a 40% reduction...Continue Reading

References

Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·R Tsuboi, D B Rifkin
Nov 3, 1995·International Journal of Cancer. Journal International Du Cancer·H KobayashiT Terao
Jan 1, 1996·Enzyme & Protein·P Mignatti, D B Rifkin
Jan 1, 1996·Current Topics in Microbiology and Immunology·B M Mueller
Mar 20, 1998·Journal of Nutritional Science and Vitaminology·Y MiyagiS Yamamoto
Jan 1, 1999·Clinical & Experimental Metastasis·X H PeiN Hara
Jun 27, 2000·Journal of Nutritional Science and Vitaminology·N AzumaK Iwami
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Mika SuzukiToshihiko Terao
Feb 18, 2003·Nutrition and Cancer·Ann R KennedyPaul M Newberne
Jun 24, 2003·Biological Chemistry·Hiroshi KobayashiToshihiko Terao
Jun 1, 2004·Clinical & Experimental Metastasis·Hiroshi KobayashiToshihiko Terao

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Citations

Jun 19, 2007·Nutrition and Cancer·David L McCormickVernon E Steele
May 24, 2006·International Journal of Toxicology·William D JohnsonDavid L McCormick
Nov 21, 2012·Nutrition and Cancer·María del Carmen Robles-RamírezRosalva Mora-Escobedo
Aug 18, 2010·Cancer Metastasis Reviews·Elvira Gonzalez de Mejia, Vermont P Dia
Mar 10, 2016·International Journal of Biological Macromolecules·Tooba Naz ShamsiSadaf Fatima
Feb 6, 2010·Journal of Biochemical and Molecular Toxicology·Soghra Khatun HaqRizwan Hasan Khan
Nov 14, 2015·Critical Reviews in Food Science and Nutrition·Blanca Hernández-Ledesma, Chia-Chien Hsieh
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Tatsuo YagyuKiyokazu Inagaki
Dec 18, 2008·Acta Biochimica Et Biophysica Sinica·Peng LinTb Ng

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