Suppressing PTEN activity by tobacco smoke plus interleukin-1beta modulates dissociation of VE-cadherin/beta-catenin complexes in endothelium

Arteriosclerosis, Thrombosis, and Vascular Biology
Silvia S BarbieriBabette B Weksler

Abstract

Tobacco smoke (TS) interacts with inflammatory cytokines to produce endothelial dysfunction. We hypothesized that interleukin-1beta (IL-1beta) plus TS (TS/IL-1beta) induces disassembly of endothelial junctional complexes of VE-cadherin/beta-catenin by suppression of PTEN activity and investigated molecular mechanisms that modulate PTEN-deactivation in this situation. TS/IL-1beta exposure, which disrupted adherens junctions and induced nuclear beta-catenin accumulation, increased tyrosine phosphorylation (p-Tyr) of VE-cadherin and beta-catenin, and reduced PTEN activity. Overexpression or silencing of PTEN modulated p-Tyr of both VE-cadherin and beta-catenin, changed assembly of adherens junction complexes, and altered nuclear beta-catenin accumulation. In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation. Finally, exposure of ApoE(-/-) mice to cigarette smoke-induced phosphorylation of Src, EGFR, p-38MAPK, PTEN, and beta-catenin, and disrupted VE-cad...Continue Reading

References

Jan 1, 1990·Advances in Experimental Medicine and Biology·H C McGill
May 28, 1993·Annals of the New York Academy of Sciences·W A Pryor, K Stone
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·G P LahvisC A Bradfield
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Adam E MullickJohn C Rutledge
Oct 9, 2002·The Journal of Biological Chemistry·Jing-Jy ChengDanny Ling Wang
Nov 14, 2002·Pharmacological Reviews·Illarion V Turko, Ferid Murad
Nov 1, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Mei LiMasatsugu Horiuchi
Apr 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Edgar A JaimesLeopoldo Raij
Apr 9, 2004·Nature Reviews. Molecular Cell Biology·Elisabetta Dejana
Jul 21, 2004·The Journal of Biological Chemistry·Erin GenschCarol Basbaum
Jan 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Larissa KotelevetsEric Chastre
Jun 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David BernhardGeorg Wick
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yingxiao WangShu Chien
Jun 24, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Joerg HerrmannAmir Lerman
Nov 7, 2006·Experimental Gerontology·David BernhardGeorg Wick
Dec 27, 2006·Cancer Letters·Masanori Kitamura, Ayumi Kasai
Feb 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Silvia S Barbieri, Babette B Weksler
Mar 21, 2007·Biochemical Society Transactions·A SuzukiT Nakano
Apr 14, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Teresa SanchezTimothy Hla

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Citations

Sep 8, 2010·Cellular and Molecular Life Sciences : CMLS·Renat ShaykhievRonald G Crystal
May 30, 2009·Analytical and Bioanalytical Chemistry·Jeffery S EdmistonWillie J McKinney
Feb 3, 2011·Cardiovascular Research·Silvia S BarbieriElena Tremoli
Jun 5, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katerina VaporidiDimitris Iliopoulos
Jul 30, 2009·Journal of Lipid Research·Raju V S Rajala
Oct 22, 2013·PloS One·George HaddadAllan G Murray
Sep 28, 2010·World Journal of Gastroenterology : WJG·Marion PeyrouMichelangelo Foti
Apr 5, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zhou-Yang JiaoXin-Ling Du
Jan 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qing LuSharon Rounds
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Satoru YanagisawaPeter J Barnes
Dec 12, 2017·Cardiovascular Research·Santa MundiRaffaele De Caterina
Feb 21, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Barbara Messner, David Bernhard
Jul 23, 2009·Journal of Cellular Biochemistry·Jenny C F WuJohn P Cooke
Mar 7, 2020·Archives of Physiology and Biochemistry·Jae-Ho KimSo-Young Park
Jul 9, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Silvia S BarbieriElena Tremoli
Jun 13, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrizia AmadioSilvia S Barbieri
Jan 15, 2013·International Journal of Molecular Medicine·Yasuko Kitagishi, Satoru Matsuda
Feb 12, 2020·Scientific Reports·Lisa DengAchim Lother
Mar 5, 2021·Aquatic Toxicology·Corinna Singleman, Nathalia G Holtzman
May 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrick Kwabena OduroQilong Wang
Jul 16, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Miriama CeresnakovaSarah P Hudson

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