Suppression by sodium valproate of gamma-vinyl GABA-induced facilitation of visual evoked potentials in rats

Electroencephalography and Clinical Neurophysiology
M S Myslobodsky, M Morag

Abstract

A single dose (500 mg/kg, i.p.) of GABA-transaminase inhibitor, gamma-vinyl GABA (GVG), administered to Wistar rats caused time-related 2--3-fold enhancement of the slow negative wave (SNW) and sensory after-discharge (SAD) of the VEP. This effect was detectable at 1 h, reached plateau at 3--4 h and remained at this level 7 h after GVG. Sodium valproate (VPA, di-n-propylacetic acid), which is also believed to block GABA-transaminase and succinic semialdehyde dehydrogenase, when administered in a dose of 200 mg/kg (i.p.) 3 h after GVG reversibly antagonized the SNW-SAD hypersynchronization. The time-course of this effect was similar to that obtained after VPA administration alone. These findings are interpreted as suggesting that VPA acts via a mechanism using a transmitter intimately connected to but not identical with GABA.

References

Jan 1, 1977·Progress in Neurobiology·R A Levy
Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·M S MyslobodskyJ Engel
Feb 1, 1979·Pharmacology, Biochemistry, and Behavior·Y Shavit, M Myslobodsky
Jul 19, 1972·Nature: New Biology·N G Bowery, D A Brown
Apr 1, 1980·Epilepsia·M S Myslobodsky, E S Valenstein

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Citations

Feb 1, 1984·Behavioural Brain Research·M S Myslobodsky, D Levin
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·B E Hetzler, H L Zeisset
May 8, 2004·Seizure : the Journal of the British Epilepsy Association·Emma J Roff HiltonTim Betts
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A VerrottiP Iannetti
Aug 9, 2007·BMC Pharmacology·Eitaute JakutieneDonatas Stakisaitis
Oct 27, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Andrew M GellerWilliam K Boyes

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