Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: Interference with the actions of an endogenous ligand, 2-arachidonoylglycerol.

European Journal of Pharmacology
Saori OkaTakayuki Sugiura

Abstract

The effect of WIN55212-2, a cannabinoid receptor agonist, on acute inflammation of mouse ear was investigated. We found that topical application of WIN55212-2 suppressed ear swelling induced by 12-O-tetradecanoylphorbol 13-acetate or 2-arachidonoylglycerol. Similar inhibition was observed with CP55940, another cannabinoid receptor agonist, and HU-308, a cannabinoid CB(2) receptor-selective agonist. WIN55212-2 also suppressed the infiltration of leukocytes induced by 12-O-tetradecanoylphorbol 13-acetate. On the other hand, WIN55212-3, an inactive enantiomer of WIN55212-2, exerted only small effects on inflammation. Notably, SR144528, a cannabinoid CB(2) receptor antagonist, also suppressed inflammatory reactions in mouse ear. Thus, both the cannabinoid CB(2) receptor agonist and antagonist are capable of reducing inflammatory reactions. We then investigated the mechanism underlying WIN55212-2-induced suppression of inflammation using cultured cells. We found that the addition of WIN55212-2 together with 2-arachidonoylglycerol blocked 2-arachidonoylglycerol-induced migration of human promyelocytic leukemia HL-60 cells that had been differentiated into macrophage-like cells. The restoration of 2-arachidonoylglycerol-desensitized c...Continue Reading

References

Jan 1, 1997·Pharmacology & Therapeutics·R G Pertwee
Apr 16, 1998·Pain·Jennelle Durnett RichardsonKenneth M Hargreaves
Jan 9, 1999·Trends in Neurosciences·V Di MarzoL De Petrocellis
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·L HanusE Fride
May 24, 2000·European Journal of Pharmacology·N E BuckleyA Zimmer
Dec 6, 2001·European Journal of Pharmacology·S R SmithC Terminelli
Apr 26, 2002·Pain·N ClaytonC T O'Shaughnessy
May 31, 2002·Pharmacological Reviews·A C HowlettR G Pertwee
Dec 31, 2002·Chemistry and Physics of Lipids·Thien P DinhDaniele Piomelli
Sep 10, 2003·Journal of Leukocyte Biology·Thomas W KleinHerman Friedman
Mar 8, 2005·Journal of Biochemistry·Seishi KishimotoTakayuki Sugiura
May 13, 2005·Journal of Pharmacological Sciences·Shigemi YoshiharaOsamu Arisaka

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Citations

Feb 8, 2011·Archives of Dermatological Research·Sofia MaginaMaria Augusta Vieira-Coelho
Nov 27, 2007·Journal of Neuroimmunology·J Ludovic CroxfordDavid Baker
Nov 6, 2007·British Journal of Pharmacology·A M Miller, N Stella
Nov 26, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·D LinderA D Cohen
May 2, 2015·Clinical Reviews in Allergy & Immunology·Nicholas K MollanazarGil Yosipovitch
Jan 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zdeněk Fišar
Jul 25, 2007·Progress in Brain Research·David M Aronoff, Andrej A Romanovsky
Apr 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonia ManducaViviana Trezza
Nov 13, 2012·Life Sciences·Melinda M Mulvihill, Daniel K Nomura
Dec 12, 2012·Neurobiology of Disease·Atsushi SaitoAtsushi Kamiya
Nov 12, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Susan FungNephi Stella
Aug 25, 2006·European Journal of Pharmacology·Olov NilssonStig O P Jacobsson
Feb 16, 2020·Clinical Drug Investigation·Amber CintosunElena Pope
Jun 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Johannes TschöpCharles C Caldwell
Dec 22, 2007·Chemistry & Biology·Peter Imming

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