Suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-κB

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ko-Woon ChoiSuhkneung Pyo

Abstract

Atherosclerosis is a chronic inflammatory disease associated with increased expression of adhesion molecules in vascular smooth muscle cells (VSMCs). The objective of this study was to examine the in vitro effects of extract from aerial Bulbil of Dioscorea batatas Decne (Db-Ex) on the ability to suppress the expression of adhesion molecules induced by TNF-α. We also identified bioactive components from a methanol extract. VSMCs pre-exposed to Db-Ex (10-100 μg/ml) were stimulated with TNF-α (10 ng/ml). Preincubation of VSMCs for 2 h with Db-Ex dose-dependently inhibited TNF-α-induced adhesion of THP-1 monocytic cells and mRNA and protein expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Db-Ex treatment decreased ROS production and the amount of phosphorylated form of p38, ERK, JNK and Akt in TNF-α-stimulated cells, suggesting that Db-Ex inhibits adhesion molecule expression possibly through MAPK and Akt regulation. Db-Ex also suppressed TNF-α-activation NK-κB. This effect was mediated through degradation of IκBα and nuclear translocation of the p65 subunit of NF-κB. These results suggest that Db-Ex inhibits monocyte adhesion and the TNF-α-mediated induction of adhesion molec...Continue Reading

References

Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Aug 1, 1993·The Journal of Clinical Investigation·P Libby, H Li
Dec 1, 1994·Journal of the American College of Cardiology·Y JangE J Topol
May 26, 1999·Cardiovascular Research·M BraunS B Felix
Aug 5, 2000·Free Radical Biology & Medicine·A K Hubbard, R Rothlein
Oct 16, 2001·Journal of Agricultural and Food Chemistry·W C HouY H Lin
Oct 27, 2001·Acta Physiologica Scandinavica·Y Huo, K Ley
Nov 7, 2003·Toxicon : Official Journal of the International Society on Toxinology·Seong-Jun ChoSuhkneung Pyo
Sep 24, 2004·Physiological Reviews·Roland Stocker, John F Keaney
Sep 28, 2005·Nature Immunology·Shintaro SatoShizuo Akira
Aug 17, 2006·Antioxidants & Redox Signaling·Michal Aharoni-SimonOren Tirosh
Apr 2, 2008·Cellular and Molecular Neurobiology·Renata P GuedesWania A Partata
Oct 18, 2008·Journal of Neuroinflammation·Melissa K McCoy, Malú G Tansey
May 6, 2009·Biochemical Pharmacology·Alexander H Sprague, Raouf A Khalil
Jul 29, 2011·Annals of the New York Academy of Sciences·Ji Yeon Kim, Oran Kwon

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Citations

Oct 16, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J JovenJ A Menéndez
Mar 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katharina SchuellerVeronika Somoza

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