PMID: 590223Dec 1, 1977

Suppression of an eplieptiform type of electrocortical activity in the rat by stimulation in the vicinity of locus coeruleus

Epilepsia
B LibetB Feinstein

Abstract

Stimulation of the locus coeruleus, or in the vicinity of this nucleus or of its ascending tracts, could markedly suppress the appearance of epileptiform-like ECoG bursts. The latter were induced in rats by a subconvulsive dose of pentylenetetrazol. Electrode sites were identified histologically. A unilateral stimulus suppressed bursts bilaterally. An individual burst already in progress could be aborted, stopping within less than 0.5-1 sec after onset of a stimulus train. The antiepileptiform actions occurred with no evidence of any desynchronizing effect of the stimulus on the resting ECoG; they appear to be different in sites of origin and nature from those reported for stimulation of the reticular activating system. It is proposed that stimulation of the ascending noradrenergic system in the brain stem may limit the development and spread of hyperexcitatory, epileptiform states.

References

Nov 1, 1975·Electroencephalography and Clinical Neurophysiology·R WagnerI L Cote
Apr 1, 1976·The Journal of Nervous and Mental Disease·M RiklanI S Cooper
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·H Kobayashi, B Libet

Citations

Feb 1, 1995·Annals of Neurology·O C Snead
Dec 1, 1986·Electroencephalography and Clinical Neurophysiology·R S Neuman
Jan 1, 1988·Electroencephalography and Clinical Neurophysiology·S Veregge, J D Frost
Jan 1, 1987·Experimental Neurology·C Jimenez-RiveraG K Weiss
Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·K Kadzielawa
Dec 1, 1994·Trends in Neurosciences·I ModyI Soltesz
Aug 1, 1985·Behavioural Brain Research·L J Ryan
Apr 26, 1982·Neuroscience Letters·J M CalvoA Fernandez-Guardiola
Apr 1, 1989·Brain Research Bulletin·C Jimenez-Rivera, G K Weiss
Aug 17, 2001·Brain Research. Developmental Brain Research·P SzotP A Schwartzkroin
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Feb 19, 2002·The European Journal of Neuroscience·D C SilveiraG L Holmes
Jan 1, 1985·Epilepsia·P Kellaway
Dec 22, 1998·Epilepsia·D C SilveiraA G Herzog
Dec 12, 2012·Surgical Neurology International·Erika E Fanselow
Oct 7, 2004·Neuroscience and Biobehavioral Reviews·Filippo S GiorgiFrancesco Fornai
Aug 7, 2004·Clinical Neurology and Neurosurgery·Sozari A ChkhenkeliIrina S Chkhenkeli
Apr 1, 1981·The Journal of Pediatrics·M A Loyola, W E Dodson
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KoideB K Siesjö
Feb 24, 1997·The Journal of Comparative Neurology·L A ZimmerM T Shipley
Nov 29, 2016·Frontiers in Neuroscience·Dubravka Svob StracGiuseppe Di Giovanni

Related Concepts

Electric Stimulation Technique
Electroencephalogram
Structure of Locus Ceruleus
Neural Inhibition
Non-epileptic Convulsion

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