Suppression of antibiotic resistance acquisition by combined use of antibiotics

Journal of Bioscience and Bioengineering
Shingo SuzukiChikara Furusawa

Abstract

We analyzed the effect of combinatorial use of antibiotics with a trade-off relationship of resistance, i.e., resistance acquisition to one drug causes susceptibility to the other drug, and vice versa, on the evolution of antibiotic resistance. We demonstrated that this combinatorial use of antibiotics significantly suppressed the acquisition of resistance.

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Citations

Apr 7, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Chikara Furusawa
Apr 28, 2017·BMC Genomics·Shingo SuzukiChikara Furusawa
Jan 23, 2021·Molecular Biology and Evolution·Leonie Johanna JahnMorten Otto Alexander Sommer

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