Suppression of antigen-specific T cell proliferation by measles virus infection: role of a soluble factor in suppression

Virology
X SunRobert S Fujinami

Abstract

Measles virus infection causes a profound immunosuppression. The basis for this immunosuppression is not known. This immunosuppression could be due to virus acting directly on lymphoid cells, the production of an immunosuppressive viral product, or a lymphoid product. We have developed an antigen-specific T cell system to study measles virus-T-cell interactions. We demonstrate that as few as five infectious viral particles added to 1000 T cells results in profound inhibition of antigen-specific T cell proliferation. Supernates taken from measles virus-infected T cells suppress the proliferation of uninfected T cells. Measles-virus-infected HeLa or Vero cells do not produce the factor. The antiproliferative effects of the supernates cannot be attributed to infectious virus, IL-10 or TGF-beta. The soluble factor appears to be larger than 100 kDa, yet retains antiproliferative activity following trypsin digestion with a size less than 10 kDa. Loss of activity is seen following heat treatment at 56 degrees C. The factor is lymphoid cell specific and exhibits cytokine-like behavior yet appears not to be a known cytokine. This soluble factor may be responsible for the overt clinical immunosuppression seen in man and a previously unde...Continue Reading

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Citations

Jun 16, 2004·Nature Reviews. Microbiology·Lauren O Bakaletz
May 8, 2009·Journal of Virology·Mary CarsilloStefan Niewiesk
Apr 9, 2010·Medical Microbiology and Immunology·Elita AvotaSibylle Schneider-Schaulies
May 5, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sarah Bruneau, Jacques Dantal
May 27, 2003·Journal of Medical Virology·Michael WangRobert S Fujinami
Oct 21, 2005·Reviews in Medical Virology·Yann M KerdilesBranka Horvat
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Jan 22, 2005·Veterinary Immunology and Immunopathology·Martina SchobesbergerChristian Griot
Feb 9, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carolina Peralta-Aros, Víctor García-Nieto
May 13, 2006·The Journal of General Virology·Sibylle Schneider-Schaulies, Ulf Dittmer

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