PMID: 6561068Jan 1, 1984Paper

Suppression of antitumor immunity by macrophages in spleens of mice bearing a large MOPC-315 tumor

Cancer Immunology, Immunotherapy : CII
Q W YeS Dray


We had shown previously that progression of MOPC-315 plasmacytoma growth is associated with an increase in the percentage of macrophages in the spleen as well as a decrease in the ability of tumor-bearer spleen cells to mount an antitumor cytotoxic response upon in vitro immunization. Here we provide evidence that macrophages in the MOPC-315 tumor-bearer spleen are responsible at least in part for the suppression of the generation of antitumor cytotoxicity. Accordingly, removal of most macrophages by depletion of phagocytic cells or Sephadex G-10-adherent cells from spleens of mice bearing a large tumor resulted in augmented antitumor immune potential. Also, Sephadex G-10-adherent spleen cells from tumor-bearing (but not normal) mice drastically suppressed the in vitro generation of antitumor cytotoxicity by normal spleen cells. The suppressive activity of these adherent cells did not reside in contaminating suppressor T cells, since it was not reduced by treatment with monoclonal anti-Thy 1.2 antibody plus complement. The Sephadex G-10-adherent cell population from the tumor-bearer spleen suppressed the in vitro generation of antitumor cytotoxicity against autochthonous tumor cells but not against allogeneic EL4 tumor cells, a...Continue Reading


Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·F CuloT Kolak
Jan 1, 1993·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I F AbroninaS N Bykovskaya
Feb 1, 1987·Perceptual and Motor Skills·A Z Arthur
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Jan 1, 1990·Medical Oncology and Tumor Pharmacotherapy·D GiacomoniS Dray

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