Suppression of apolipoprotein M expression and secretion in alloxan-diabetic mouse: Partial reversal by insulin

Biochemical and Biophysical Research Communications
Ning XuBo Ahrén

Abstract

We previously reported that apolipoprotein M (apoM) expression is reduced in ob/ob mice. Whether such a reduction is specific for this model or is a more general phenomenon in diabetes models is not known. In the present study, we therefore investigated apoM expression and secretion in NMRI mice rendered diabetes through administration of alloxan (120 mg/kg). Plasma glucose levels were markedly increased and plasma insulin levels markedly reduced at 3 days after alloxan. At the same time, that plasma apoM concentrations were decreased by 70%, apoM mRNA levels in liver was decreased by 40%, and apoM mRNA in kidney was decreased by 20% in alloxan-treated mice compared to saline-injected controls. Furthermore we found also that daily sc administration of insulin (5 IU/kg per day) increased plasma apoM levels, and apoM mRNA levels in liver and kidney. We therefore conclude that apoM is reduced in this diabetes model and that exogenous insulin administrations partially reverses the abnormal apoM expression. Based on these results, we suggest that insulin regulates apoM synthesis in vivo and, therefore, that the reduction of apoM expression is a general phenomenon in diabetes models.

References

Nov 1, 1983·The Journal of Surgical Research·R H Bell, R J Hye
Oct 26, 1999·The Journal of Biological Chemistry·N Xu, B Dahlbäck
Nov 4, 2000·Biochimica Et Biophysica Acta·D R FlowerC E Sansom
Nov 4, 2000·Biochimica Et Biophysica Acta·E RassartR Milne
May 19, 2004·Acta histochemica·Xiao-Ying ZhangNing Xu
Sep 11, 2004·Biochemical and Biophysical Research Communications·Ning XuBo Ahrén
Nov 16, 2004·The Journal of Nutritional Biochemistry·Ning XuBo Ahrén

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Citations

Jul 28, 2010·The Journal of Biological Chemistry·Ioanna MosialouDimitris Kardassis
Jan 30, 2009·Diabetes, Obesity & Metabolism·C BrorssonUNKNOWN Diabetes Genetics Consortium
Sep 18, 2010·Lipids in Health and Disease·Guanghua LuoNing Xu
Mar 14, 2008·The Review of Diabetic Studies : RDS·Jan SkupienMaciej T Malecki
Apr 23, 2015·Molecular Medicine Reports·Li-Zhu HuangYao Zhang
Apr 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kun RenGuang-Hui Yi
Mar 10, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alessandra di MasiPaolo Ascenzi
Jan 16, 2007·Medical Hypotheses·Xian-sheng HuangYang-ping Luo
Jun 9, 2007·Biochimica Et Biophysica Acta·Xiaoying ZhangNing Xu
Jul 21, 2017·Journal of Atherosclerosis and Thrombosis·Makoto Kurano, Yutaka Yatomi
Nov 15, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·C ChristoffersenL B Nielsen
Mar 6, 2021·JACC. Basic to Translational Science·Thomas C HanffJulio A Chirinos
Jun 8, 2021·Frontiers in Endocrinology·Christina Christoffersen

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