Suppression of apoptotic cell death by hepatitis C virus core protein

Virology
R B RayR Ray

Abstract

We have previously demonstrated the role of hepatitis C virus (HCV) core protein in the transcriptional regulation of cellular and unrelated viral promoters. Furthermore, the core protein in cooperation with H-ras oncogene transforms primary rat embryo fibroblast cells to the tumorigenic phenotype. In the present study, the functional role of HCV core protein was investigated to determine its potential to inhibit the onset of apoptotic cell death. Expression of HCV core protein inhibited cisplatin mediated apoptosis in human cervical epithelial cells, and apoptosis induced by the overexpression of c-myc in Chinese hamster ovarian cells. Results from these studies suggest that the core protein may have a biological implication in the pathogenesis of HCV infection.

Citations

Feb 13, 2001·British Journal of Haematology·E ZuckermanJ Rowe
Dec 3, 1999·European Journal of Clinical Investigation·F L DumoulinU Spengler
Sep 6, 2000·Journal of Internal Medicine·H KuperD Trichopoulos
Aug 7, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kristen MillerStephen J Polyak
Jul 7, 2011·PloS One·Hussein Hassan AlyTsukasa Seya
Mar 20, 2008·World Journal of Gastroenterology : WJG·Patrick Arbuthnot, Liam-Jed Thompson
Jun 30, 2000·Biochemical and Biophysical Research Communications·F WangH Hotta
Aug 5, 2011·Gut and Liver·Jae Young Jang, Raymond T Chung
Jun 5, 2004·Virus Research·A R CiccaglioneM Rapicetta
Sep 11, 2001·Biochemical and Biophysical Research Communications·N Acosta-RiveroJ Morales
Jan 1, 2010·International Journal of Proteomics·Toshinori OzakiAkira Nakagawara
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal M HassanYehuda Z Patt
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kui LiMichael R Beard
Jul 12, 2002·Journal of Gastroenterology·Kunitada ShimotohnoMakoto Hijikata
Dec 22, 1999·Journal of Viral Hepatitis·N Hayashi, E Mita
Sep 5, 2002·The Journal of Pathology·Laura Rubbia-BrandtFrancesco Negro
Apr 26, 2007·Folia Microbiologica·L KrekulováL W Riley
Jul 29, 2005·Digestive Diseases and Sciences·Atsushi YamaguchiKazuaki Chayama
Jan 5, 2002·Microbiology and Immunology·I YoshidaH Hotta
Apr 29, 2009·Journal of Cancer Research and Clinical Oncology·Long WuYan Li
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F CalabreseM Valente

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis