PMID: 6462530Jun 1, 1984Paper

Suppression of arterial pressure, heart rate and cardiac contractility following microinjection of kainic acid into the nucleus ambiguus of the rat

Neuroscience Letters
S H ChanP T Wong


In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart contractility reduction (50.7%) greater than hypotension (28.9%) greater than bradycardia (20.8%) at the end of a 60-min postinjection period. We concluded that the nucleus ambiguus may exert its control on cardiac activities by both negative chronotropic and inotropic effects on the heart.


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Aug 1, 1987·Journal of Pharmacological Methods·S H Chan, B T Ong

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