PMID: 6462530Jun 1, 1984Paper

Suppression of arterial pressure, heart rate and cardiac contractility following microinjection of kainic acid into the nucleus ambiguus of the rat

Neuroscience Letters
S H ChanP T Wong

Abstract

In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart contractility reduction (50.7%) greater than hypotension (28.9%) greater than bradycardia (20.8%) at the end of a 60-min postinjection period. We concluded that the nucleus ambiguus may exert its control on cardiac activities by both negative chronotropic and inotropic effects on the heart.

References

Jul 1, 1978·Annals of Neurology·E A Singh, E G McGeer
Jul 1, 1979·The Journal of Comparative Neurology·S NosakaK Yasunaga
Apr 30, 1979·Pflügers Archiv : European journal of physiology·S NosakaM Kawano
Jan 1, 1975·Progress in Neurobiology·F R CalaresuG J Mogenson
Jun 1, 1976·The Journal of Physiology·R M McAllen, K M Spyer
Jan 1, 1982·Journal of the Autonomic Nervous System·J Ciriello, F R Calaresu
Apr 1, 1981·Journal of the Autonomic Nervous System·G S GeisR D Wurster

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Citations

Aug 1, 1987·Journal of Pharmacological Methods·S H Chan, B T Ong

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