Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase

Carcinogenesis
T TanakaA Hara

Abstract

The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks and then they were fed the diets containing AX or CX at concentrations of 100 and 500 p.p.m. for 34 weeks. The others contained the groups of rats treated with AX or CX alone and untreated. At the end of the study (week 37), the incidence and multiplicity of neoplasms (adenoma and adenocarcinoma) in the large intestine of rats initiated with AOM and followed by AX or CX containing diet at a high dose (500 p.p.m.) were significantly smaller than those of rats given AOM alone (P < 0.001). In addition, AX or CX feeding significantly inhibited the development of aberrant crypt foci induced by AOM. Dietary exposure to AX or CX also decreased cell proliferation activity as revealed by measuring 5'-bromodeoxyuridine-labeling index as crypt cells, colonic mucosal ornithine decarboxylase activity and blood polyamine levels. These results indicate that AX and CX are possible chemopreventers for carcinogenesis of colon in ad...Continue Reading

Citations

Nov 11, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michiyuki SaitoShigeaki Ohno
Mar 17, 2010·Cell Biology and Toxicology·Anaysa P BolinRosemari Otton
Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·T Tanaka
Mar 31, 2000·Trends in Biotechnology·R T Lorenz, G R Cysewski
May 3, 2003·Trends in Biotechnology·Martin GuerinMiguel Olaizola
Apr 1, 1997·Critical Reviews in Oncology/hematology·T Tanaka
Oct 13, 1999·Mutation Research·H MoriT Tanaka
May 12, 2000·Proceedings of the Society for Experimental Biology and Medicine·T NarisawaT Inakuma
Jan 25, 2006·Critical Reviews in Food Science and Nutrition·I Higuera-CiaparaF M Goycoolea
Jun 14, 2003·Journal of Medicinal Food·Gene A Spiller, Antonella Dewell
Jan 10, 2014·Marine Drugs·Ranga Rao AmbatiRavishankar Gokare Aswathanarayana
Feb 1, 2014·Food & Function·Jie ZhangFeng Chen
May 9, 2014·Applied Microbiology and Biotechnology·Purnima SinghGuangyi Wang
Mar 31, 2015·Seminars in Cancer Biology·Dass S VinayByoung S Kwon
Oct 6, 2015·Marine Drugs·Elena TaleroVirginia Motilva
Dec 25, 2012·Trends in Biotechnology·Helena M AmaroF Xavier Malcata
May 19, 2009·International Journal of Pharmaceutics·Amornset TachaprutinunSupason Wanichwecharungruang
Dec 17, 2015·Archives of Pharmacal Research·Pravin Nalawade, Anuradha Gajjar
Apr 1, 2011·Biotechnology Progress·A Catarina GuedesF Xavier Malcata
Nov 24, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Gladis N Coral-HinostrozaBjørn Bjerkeng
May 10, 2005·European Journal of Pharmacology·Jeong-Hwan KimHyo-Ihl Chang
Mar 9, 2013·Journal of Oleo Science·Takashi MaokaTakashi Ishibashi
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Hasina BegumMohamed Shariff
Jun 1, 2010·Archives of Oral Biology·Mariana Ferreira LeiteRosemari Otton
Jul 1, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·John S StewartM G Soni
Oct 1, 2016·Molecular Nutrition & Food Research·Tuba Esatbeyoglu, Gerald Rimbach
Mar 1, 2012·International Journal of Toxicology·Anbarasu KumarVijayalakshmi Govindaswamy
May 8, 2000·Nutrition and Cancer·H JyonouchiM D Gross

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.