Suppression of B-memory cell function by polyclonal lymphocyte activators

Immunobiology
T YokochiN Kato

Abstract

When various polyclonal lymphocyte activators (PLA), such as the capsular polysaccharide of Klebsiella pneumoniae (CPS-K), E. coli lipopolysaccharide (LPS), concanavalin A (Con A), dextran sulfate (DS), phytohemagglutinin (PHA), and pokeweed mitogen (PWM) were injected into mice primed with sheep red blood cells (SRBC), anti-SRBC secondary plaque-forming cell (PFC) responses in vitro of their spleen cells to SRBC and to polyclonal B cell activatory (PBA) were more or less decreased. The decrease in the responsiveness was accompanied by the decrease in the number of SRBC-specific rosette-forming cells (RFC) of B-cell type (B memory cells). This resulted neither from emigration of RFC out of the spleen, nor from change of RFC to antibody-forming cells. Further, we revealed that the decreased responsiveness occurs exclusively in the B cell-rich fraction of the spleen cells from PLA-treated SRBC-primed mice, but not in their T cell-rich fraction. It is concluded therefore that PLA exhibited a common action to reduce selectively B-memory cell function by decreasing the number of B memory cells without differentiation to their end cells, although the strength of the action of various PLA varied.

References

Jul 1, 1973·The Journal of Infectious Diseases·O LüderitzO Westphal
Jan 19, 1972·Nature: New Biology·M F Greaves, S Bauminger
Jun 1, 1972·European Journal of Immunology·J AnderssonO Sjöberg
Aug 1, 1972·Cellular Immunology·J AnderssonO Sjöberg
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J Andersson, F Melchers
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Mar 1, 1974·European Journal of Immunology·R DörriesE Wecker
Nov 1, 1974·European Journal of Immunology·E Gronowicz, A Coutinho

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Citations

Apr 1, 1986·Cellular Immunology·D L Burg, T L Feldbush

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