Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y.

Endocrinology
Jing XuM Susan Smith

Abstract

Increased neuropeptide Y (NPY) activity drives the chronic hyperphagia of lactation and may contribute to the suppression of GnRH activity. The majority of GnRH neurons are contacted by NPY fibers, and GnRH cells express NPY Y5 receptor (Y5R). Therefore, NPY provides a neurocircuitry for information about food intake/energy balance to be directly transmitted to GnRH neurons. To investigate the effects of lactation on GnRH neuronal activity, hypothalamic slices were prepared from green fluorescent protein-GnRH transgenic rats. Extracellular loose-patch recordings determined basal GnRH neuronal activity from slices of ovariectomized control and lactating rats. Compared with controls, hypothalamic slices from lactating rats had double the number of quiescent GnRH neurons (14.51 +/- 2.86 vs. 7.04 +/- 2.84%) and significantly lower firing rates of active GnRH neurons (0.25 +/- 0.02 vs. 0.37 +/- 0.03 Hz). To study the NPY-postsynaptic Y5R system, whole-cell current-clamp recordings were performed in hypothalamic slices from control rats to examine NPY/Y5R antagonist effects on GnRH neuronal resting membrane potential. Under tetrodotoxin treatment, NPY hyperpolarized GnRH neurons from -56.7 +/- 1.94 to -62.1 +/- 1.83 mV; NPY's effects...Continue Reading

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Citations

Sep 3, 2010·Brain Research·Martin J Kelly, Jian Qiu
Sep 8, 2010·Brain Research·Oline K RønnekleivChunguang Zhang
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Min WuMeenakshi Alreja
May 20, 2011·Journal of Neuroendocrinology·O K RønnekleivC Zhang
Sep 25, 2012·Frontiers in Neuroendocrinology·Barbara WoodsideAlfonso Abizaid
Oct 9, 2012·Frontiers in Neuroendocrinology·T J StevensonG F Ball
Apr 23, 2010·Endocrinology·Janardhan P BhattaraiIstván M Abrahám
Nov 6, 2015·Frontiers in Endocrinology·Valérie Simonneaux, Thibault Bahougne
Mar 23, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Shuwen TanHua Li

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