Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications.

Arthritis Research & Therapy
Manolis Heliotis, Eleftherios Tsiridis

Abstract

Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin (a well recognized BMP inhibitor) and BMP-2 are expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin inhibition induces human mesenchymal stem cell differentiation and reduces their proliferation by increasing BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering, because it results in an unopposed synergy between the various growth factors that are involved in osteogenesis, within their physiological milieu.

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Citations

Jan 27, 2016·Arthritis Research & Therapy·Samantha C W ChanBenjamin Gantenbein
Dec 10, 2008·Expert Opinion on Therapeutic Targets·Evaggelos TsialogiannisEleftherios Tsiridis
Jan 15, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kari PollockJan A Nolta
Jun 23, 2018·Journal of Cellular Biochemistry·Alann T P SouzaMarcio M Beloti
Feb 9, 2021·Chemistry of Materials : a Publication of the American Chemical Society·Soyon Kim, Min Lee
Sep 11, 2017·ACS Biomaterials Science & Engineering·Cong Truc HuynhEben Alsberg

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