PMID: 11322996Apr 27, 2001Paper

Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms

Mechanisms of Ageing and Development
Mark P MattsonZ Guo

Abstract

Dietary restriction (reduced calorie intake with nutritional maintenance) can extend lifespan and may increase the resistance of the nervous system to age-related diseases including neurodegenerative disorders. An environment enriched in intellectual and physical activities can also allay many of the adverse effects of aging on the brain. The mechanisms underlying the beneficial effects of dietary restriction and environmental enrichment on the brain involve stimulation of the expression of neurotrophic factors and 'stress proteins'. The neurotrophic factors and stress proteins induced by dietary restriction may protect neurons by suppressing oxyradical production, stabilizing cellular calcium homeostasis and inhibiting a form of programmed cell death called apoptosis. Interestingly, dietary restriction and environmental enrichment also increase numbers of newly-generated neural cells in the adult brain suggesting that these behavioral modifications can increase the brain's capacity for plasticity and self-repair. A better understanding of the cellular and molecular mechanisms underlying these effects of diet and behavior on the brain is leading to novel therapeutic agents that mimick their beneficial effects.

References

Nov 1, 1989·Developmental Psychobiology·J E BlackW T Greenough
Jan 1, 1987·Journal of Gerontology·D K IngramR L Walford
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Nov 23, 1995·The New England Journal of Medicine·L L BronnerJ E Manson
Feb 1, 1996·Stroke; a Journal of Cerebral Circulation·B B Johansson
Mar 1, 1997·Neuroscience and Biobehavioral Reviews·M P Mattson
Feb 1, 1997·Mechanisms of Ageing and Development·C C SpauldingR B Effros
Mar 1, 1997·Progress in Cardiovascular Diseases·W D Schell, J N Myers
May 8, 1998·Molecular Medicine Today·W J RayA M Goate
Jul 14, 1998·Nature Medicine·C GeulaB A Yankner
Jan 8, 1999·Stroke; a Journal of Cerebral Circulation·I M LeeJ E Manson
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Oct 12, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Russo-NeustadtC W Cotman
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Levi
Feb 19, 2000·Current Opinion in Neurobiology·S MommaJ Frisén
Feb 26, 2000·Journal of Molecular Neuroscience : MN·W A PedersenM P Mattson
Apr 14, 2000·Journal of Cardiopulmonary Rehabilitation·M BrochuP A Ades
Jul 13, 2000·Brain Research. Molecular Brain Research·K Eckles-SmithM D Browning
Sep 27, 2005·Current Neurovascular Research·Oleksandr Ekshyyan, Tak Yee Aw
Jul 1, 2008·Journal of General Internal Medicine·Adrianne C FeldsteinNancy Perrin

❮ Previous
Next ❯

Citations

Jul 20, 2007·European Archives of Psychiatry and Clinical Neuroscience·H Georg KuhnPaul J Lucassen
Sep 2, 2008·Molecular Neurobiology·Angela Fontán-LozanoAngel Manuel Carrión
May 10, 2002·Trends in Neurosciences·Catherine A Wolkow
Oct 24, 2002·Neurobiology of Aging·Robert A Floyd, Kenneth Hensley
Oct 24, 2002·Neurobiology of Aging·Shlomo YehudaDavid I Mostofsky
Feb 28, 2003·Neuroscience·M AperghisG Goldspink
Aug 31, 2004·Lab Animal·Nancy L Nadon
Nov 9, 2010·Oncogene·A Martín-MontalvoR de Cabo
Aug 8, 2008·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Helga Noice, Tony Noice
Sep 30, 2005·Proceedings. Biological Sciences·Duane B FonsecaMatt R J Sheehy
May 15, 2007·Dementia and Geriatric Cognitive Disorders·Marie-Laure AncelinKaren Ritchie
Nov 13, 2010·Developmental Neuroscience·Talin BabikianChristopher C Giza
Oct 27, 2009·Ageing Research Reviews·Stephen R Spindler
Oct 24, 2007·Behavioural Brain Research·Marie-Claude RobergeHélène Plamondon
Aug 7, 2007·Physiology & Behavior·Mikael AltunBrun Ulfhake
Feb 17, 2007·Neurobiology of Learning and Memory·P M D NippakN W Milgram
Oct 16, 2004·The Journal of Pharmacy and Pharmacology·A W MichellR A Barker
Sep 19, 2007·Aging Cell·Poonam BhandariMichael S Grotewiel
Aug 22, 2006·Neurobiology of Aging·Hongyan JiangSu-Hua Sha
Feb 21, 2014·Expert Review of Neurotherapeutics·Aya D PusicRichard P Kraig
Nov 29, 2005·Hearing Research·Susan T FrisinaRobert D Frisina
Jun 18, 2005·Biochemical and Biophysical Research Communications·Lingzhi Li, Bor Luen Tang
May 23, 2007·Aging Cell·David Murchison, William H Griffith
Dec 4, 2012·Experimental Gerontology·K W ChungH Y Chung
Jan 24, 2006·Molecular Cell·Antonella RiccioDavid D Ginty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis