Suppression of carbachol-induced oscillatory Cl- secretion by forskolin in rat parotid and submandibular acinar cells

American Journal of Physiology. Gastrointestinal and Liver Physiology
Takahide ShintaniY Shiba

Abstract

Sympathetic stimulation induces weak salivation compared with parasympathetic stimulation. To clarify this phenomenon in salivary glands, we investigated cAMP-induced modulation of Ca(2+)-activated Cl(-) secretion from rat parotid and submandibular acinar cells because fluid secretion from salivary glands depends on the Cl(-) secretion. Carbachol (Cch), a Ca(2+)-increasing agent, induced hyperpolarization of the cells with oscillatory depolarization in the current clamp mode of the gramicidin-perforated patch recording. In the voltage clamp mode at -80 mV, Cch induced a bumetanide-sensitive oscillatory inward current, which was larger in rat submandibular acinar cells than in parotid acinar cells. Forskolin and IBMX, cAMP-increasing agents, did not induce any marked current, but they evoked a small nonoscillatory inward current in the presence of Cch and suppressed the Cch-induced oscillatory inward current in all parotid acinar cells and half (56%) of submandibular acinar cells. In the current clamp mode, forskolin + IBMX evoked a small nonoscillatory depolarization in the presence of Cch and reduced the amplitude of Cch-induced oscillatory depolarization in both acinar cells. The oscillatory inward current estimated at the de...Continue Reading

References

Mar 1, 1992·The American Journal of Physiology·J E Melvin, R J Turner
Apr 1, 1992·The Journal of Clinical Investigation·M Paulais, R J Turner
Dec 1, 1992·The American Journal of Physiology·B Nauntofte
Feb 1, 1987·Pflügers Archiv : European journal of physiology·D PiraniJ A Young
Feb 1, 1987·Journal of Dental Research·J A YoungD Pirani
Jan 1, 1985·The Japanese Journal of Physiology·N IwatsukiA Nishiyama
May 1, 1995·The Journal of Physiology·J ArreolaT Begenisich
Jan 1, 1995·Neuroscience·Y AbeN Akaike
Jan 1, 1995·Histochemistry and Cell Biology·C HironoY Kanno
Sep 1, 1994·The American Journal of Physiology·H Izumi, K Karita
Sep 20, 1993·Annals of the New York Academy of Sciences·R J Turner
Feb 11, 1996·The American Journal of Physiology·C Lytle, B Forbush
Jul 1, 1996·The Journal of General Physiology·J ArreolaT Begenisich
Jan 15, 1996·The Journal of Physiology·J ArreolaT Begenisich
Jan 1, 1996·Progress in Biophysics and Molecular Biology·N Akaike
Jan 1, 1997·Pflügers Archiv : European journal of physiology·X HeB J Baum
Jan 1, 1997·Acta Physiologica Scandinavica·J GromadaS Dissing
Jan 5, 2000·Physiological Reviews·J M Russell
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J E Melvin
Jun 9, 2000·Annual Review of Physiology·M Haas, B Forbush
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M K ParkO H Petersen
Mar 23, 2004·Biochemical and Biophysical Research Communications·Patricia Perez-Cornejo, Jorge Arreola
Jul 21, 2004·The Journal of Biological Chemistry·David A BrownDavid I Yule
Aug 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·A R HarmerD V Gallacher
Nov 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Catia Sternini

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Citations

Oct 19, 2012·Clinical and Experimental Pharmacology & Physiology·Takahiro K ImamuraYoichi Nakagawa
Mar 27, 2015·Neurourology and Urodynamics·Sherif S HassanMagdy F Youakeem
Jan 1, 2009·The Journal of Medical Investigation : JMI·Chikara HironoYoshiki Shiba
Mar 14, 2014·American Journal of Physiology. Renal Physiology·Manami KidokoroRyuji Hosokawa

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