Suppression of carcass weight loss in cachexia in rats bearing Leydig cell tumor by the novel compound NO-1886, a lipoprotein lipase activator

Metabolism: Clinical and Experimental
M OharaN Ohsawa

Abstract

The Leydig cell tumor has been reported to produce tumor necrosis factor (TNF) and induce cachexia in rats. TNF is thought to reduce lipoprotein lipase (LPL) activity, decrease fat deposits, induce emaciation, and worsen cachexia. Therefore, we thought emaciation might be prevented and thus cachexia improved by increasing LPL activity. We administered NO-1886, a lipoprotein lipase activator, to rats bearing Leydig cell tumor and observed its effect on improving the cachexia induced by the tumor. In Leydig cell tumor-bearing rats, the emaciation progressed after tumor inoculation and the general condition worsened daily. Plasma levels of total protein, albumin, and glucose, which are biological parameters of malnutrition, were found to decrease soon after tumor inoculation in tumor-bearing rats. In contrast, rats given NO-1886 showed less malnutrition than tumor-bearing rats. LPL activity of rat adipose tissue was decreased, the weight of adipose tissue was decreased, carcass weight was reduced, and food consumption was decreased after Leydig cell tumor inoculation. NO-1886 increased adipose tissue LPL activity and suppressed the decrease in the weight of adipose tissue, carcass weight, and food consumption due to cachexia witho...Continue Reading

References

Oct 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H VlassaraA Cerami
Sep 1, 1981·The Journal of Experimental Medicine·M Kawakami, A Cerami
Jun 26, 1995·Biochemical and Biophysical Research Communications·M ShimadaY Yazaki

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Citations

Aug 18, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nabila Bennani-Baiti, Declan Walsh
Apr 9, 2002·Current Oncology Reports·Fade Aziz Mahmoud, Nilo I Rivera
Jan 17, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Weidong YinKechao Tang
Oct 24, 2002·Biological & Pharmaceutical Bulletin·Kazuhiko TsutsumiYasunori Kondo
Aug 16, 2016·Life Sciences·Fernando Tadeu Trevisan FrajacomoRafael Deminice
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Frédéric PicardYves Deshaies
Mar 17, 2004·Phytotherapy Research : PTR·Jeong-Yeh YangJin-Woo Park

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